Published November 30, 2024
| Version v2
Dataset
Open
Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosis
Authors/Creators
-
1.
Universitätsklinikum Aachen
-
2.
RWTH Aachen University
- 3. Pathology & Imaging, Global Drug Development, Novo Nordisk A/S
- 4. Digital Science and Innovation, Computational Biology – AI & Digital Research, Novo Nordisk A/S
Description
Here we generate an integrative high-resolution map of human atherosclerotic plaques combining single-cell RNA-seq from multiple studies and spatial transcriptomics data from 12 human specimens, with different stages of atherosclerosis. We show cell-type and atherosclerosis-specific expression changes and spatially constrained alterations in cell-cell communication.
Files
10_ Atheroma.jpg
Files
(8.4 GB)
| Name | Size | Download all |
|---|---|---|
|
md5:df3c7f7dc2d42ad8a834a10d57538bc5
|
70.4 MB | Preview Download |
|
md5:93c5a9c4158d1f1685f9aec2504b6e64
|
71.0 MB | Preview Download |
|
md5:780bd51a27d820e3e87b84a141bc7ff1
|
72.7 MB | Preview Download |
|
md5:06621e8ba5490ae2f27ad7b010638f36
|
76.7 MB | Preview Download |
|
md5:2876787d9408f8778c456b495b01c856
|
68.4 MB | Preview Download |
|
md5:e8793a8707a9f77a04b4f49ce841bac4
|
90.7 MB | Preview Download |
|
md5:0d3cd5c71794ce628f25ac5833a39dc8
|
79.7 MB | Preview Download |
|
md5:9674dca66a26aece037b11cd089818d3
|
71.7 MB | Preview Download |
|
md5:3b139bb4e0b811ec95b99c35279d4f35
|
71.5 MB | Preview Download |
|
md5:21a46f43caddb4ff12b4ed8f53714ab6
|
66.1 MB | Preview Download |
|
md5:f03ea73056847862c34c35a9192e13d8
|
70.1 MB | Preview Download |
|
md5:672b92dee765ce9586a93e30deffa1a6
|
61.7 MB | Preview Download |
|
md5:0c273f8bca15d25ff686b8fe2cac7fdf
|
6.6 GB | Download |
|
md5:eb27517d71467c8b25664bc324d1a1ed
|
1.0 GB | Download |
Additional details
Software
- Repository URL
- https://github.com/hayatlab/multiomics_athero_atlas