Data for: Epigenetic Age and Long-Term Cancer Risk Following a Stroke

Data for Manuscript: "Epigenetic Age and Long-Term Cancer Risk Following a Stroke"

In this study, we investigated whether stroke patients who later developed cancer exhibited an accelerated epigenetic age compared to those who did not. A total of 648 stroke patients were followed for 15 years, during which 83 individuals were diagnosed with cancer. Biological age (B-age) was estimated from DNA methylation data derived from whole blood samples collected within 24 hours of stroke onset. These samples were analyzed using the 450K or EPIC Illumina Beadchip arrays. We employed several epigenetic clocks to calculate B-age, including the Hannum, Horvath, PhenoAge, ZhangBLUP, ZhangEN, and the mitotic epiTOC clocks.

After adjusting for multiple testing, competing risks, and key confounders, we found that patients who developed cancer were biologically older, as measured by the Hannum clock.

This repository provides the associated phenotypic data, estimated white cell counts and B-age estimations, including both raw data and age acceleration values.