Published 2023 | Version v2
Poster Open

INVESTIGATING THE EFFECT OF CISPLATIN ON THE VIABILITY OF CO-CULTURED CANDIDA ALBICANS AND PATIENT-DERIVED ORAL SQUAMOUS CELL CARCINOMA CELLS

Authors/Creators

  • 1. Precision Medicine Lab, CECOS-RMI
  • 2. Beaconhouse Margalla Campus, Islamabad
  • 3. Institute of Integrative Biosciences, CECOS University
  • 4. Department of Bioengineering, University of Engineering and Applied Sciences, Swat,
  • 5. Centre for Genomic Sciences, Rehman Medical Institute

Description

Candida albicans: a yeast species commonly found in the oral cavity, has raised intriguing questions about oral cancer. Literature has shown a higher prevalence of yeast and greater diversity in oral cancer patients, with C. albicans playing a pivotal role (1). It has the potential to convert alcohol into the carcinogen acetaldehyde through the CaADH1 mRNA gene (2). We studied the impact of co-cultured C.albicans with oral squamous cell carcinoma cell line in the presence of cisplatin and acetaldehyde.

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Additional details

References

  • 1) Perera, Manosha, et al. "A dysbiotic mycobiome dominated by Candida albicans is identified within OSCC." J Oral Microbiol vol. 9 (2017).
  • 2) Hafed, Layla et al. "Candida Albicans Alcohol Dehydrogenase 1 gene in oral dysplasia and OSCC." Pol J Pathol vol. 70 (2019).