Published 2023
| Version v2
Poster
Open
CAN THE ADENINE ANALOGUE 6 HYDROXYL AMINO PURINE INHIBIT THE GROWTH OF CANCER?
Authors/Creators
- 1. Precision Medicine Lab, CECOS-RMI
- 2. International Islamic University Islamabad, School and College
- 3. Department of Bioengineering, University of Engineering and Applied Sciences, Swat
- 4. Institute of Integrative Biosciences, CECOS University
- 5. Centre for Genomic Sciences, Rehman Medical Institute
Description
6HAP, an adenine analogue, disrupts DNA synthesis and kills cancer cells. As yet, it’s known to be naturally produced by two Staphylococcus epidermidis strains (M034 and M038). 6HAP has anti-tumour effects on various cancer cell lines (1). 6HAP sensitivity in cancer cells is due to down regulated mitochondrial amidoxime-reducing component enzymes (mARC1 and mARC2), leading to apoptosis. The downregulation of these enzyme genes and the biosynthesis of 6HAP in Staphylococcus epidermidis, however, remain largely unknown.
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Additional details
References
- 1) Nakatsuji T et al 2018 . A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv.