Published 2024 | Version v2
Poster Open

Neuronal Activity Characterization in Molecular Subtypes of Small Cell Lung Carcinoma

Authors/Creators

  • 1. ROR icon Khyber Medical College
  • 2. Precision Medicine Lab, CECOS-RMI
  • 3. Institute of Integrative Biosciences, CECOS University
  • 4. Centre for Genomic Sciences, Rehman Medical Institute

Description

Small Cell Lung Carcinoma (SCLC) is a highly aggressive neuroendocrine malignancy, representing about 15% of lung cancers, and is marked by rapid progression, early metastasis, and high mortality (1). Significant heterogeneity exists in SCLC, characterized by the existence of distinct molecular subtypes that are determined by the varying expression of transcription factors such as ASCL1, NEUROD1, and POU2F3, each linked to unique biological behaviors and therapeutic responses (2). Additionally, recent studies have found a connection between neuronal activity and the development of both primary and metastatic SCLC (3).

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Additional details

References

  • 1) Wang, Q. et al. (2023) "SCLC: Epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection."
  • 2) Gay, C.M. et al. (2021) "Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities."
  • 3) Savchuk, S. et al. (2023) "Neuronal-Activity dependent mechanisms of small cell lung cancer progression."