Published 2022 | Version v1
Poster Open

Decomposing the role of Fusobacterium nucleatum in head and neck squamous cell carcinoma by learning from colorectal cancer using protein interaction networks.

Authors/Creators

  • 1. Atta ur Rehman School of Biological Sciences, National University of Science and Technology
  • 2. Precision Medicine Lab, CECOS-RMI
  • 3. Institute of Integrative Biosciences, CECOS University
  • 4. Department of Bioengineering, University of Engineering and Applied Sciences, Swat

Description

Numerous members of the human microbiome including P. gingivalis, E. coli, H. pylori and F. nucleatum have been implicated in the onset of cancer. F. nucleatum, a gram-negative opportunistic bacterium, is implicated in establishing disease-favourable environment in colorectal cancer (CRC), breast cancer, esophageal cancer, oral squamous cell carcinoma (OSCC).  F. nucleatum is also reported to cause chronic inflammation in head and neck squamous cell carcinoma (HNSCC) one of the most prevalent cancer groups in Pakistan. This study aims to highlight key players common in both CRC and HNSCC that interact with F. nucleatum indicating similar mechanism of that may favor the onset of cancer. 

 

Files

Khired.pdf

Files (702.4 kB)

Name Size Download all
md5:e4758121f942dbd13b83db9d17fc7b26
702.4 kB Preview Download

Additional details

References

  • Zanzoni, A., Spinelli, L., Braham, S. et al. Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins. Microbiome 5, 89 (2017). https://doi.org/10.1186/s40168-017-0307-1
  • Kumar, A., Thotakura, P.L., Tiwary, B.K. et al. Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions. BMC Microbiol 16, 84 (2016). https://doi.org/10.1186/s12866-016-0700-0.
  • Zhang, S., Cai, S., & Ma, Y. (2018). Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. Journal of Cancer, 9(9), 1652–1659. https://doi.org/10.7150/jca.24048.