Published 2024
| Version v1
Poster
Open
Exploring the Transcriptomic Profiles and Links Between Cholelithiasis and Cholangiocarcinoma
Authors/Creators
-
1.
Khyber Medical College
- 2. Precision Medicine Lab, CECOS-RMI
- 3. Centre for Genomic Sciences, Rehman Medical Institute
- 4. Institute of Integrative Biosciences, CECOS University
Description
Cholangiocarcinoma (CCA) is a rare and fatally aggressive cancer of the biliary tract. Due to its heterogeneous nature, silent presentation, and wavering response to chemotherapy, CCA-associated mortality accounts for ~2% of cancer-afflicted deaths yearly[1]. Cholelithiasis/gallstones (GS) are hardened deposits, usually cholesterol, that form in the gallbladder (GB) and cause severe symptoms mainly inflammation and abdominal pain. They have been termed a possible risk factor for CCA however no definitive link or evidence exists on the molecular level [2,3].
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Additional details
References
- Brindley, P.J., Bachini, M., Ilyas, S.I. et al. Cholangiocarcinoma. Nat Rev Dis Primers 7, 65 (2021).
- Lammert, F., Gurusamy, K., Ko, C. et al. Gallstones. Nat Rev Dis Primers 2, 16024 (2016).
- Hsing, A W et al. "Gallstones and the risk of biliary tract cancer: a population-based study in China." British journal of cancer vol. 97,11 (2007): 1577-82.