Published 2023 | Version v1
Poster Open

Investigating the role of chemokines and chemokine-receptors in the metastasis of breast cancer subtypes

Authors/Creators

  • 1. Precision Medicine Lab (CECOS RMI)
  • 2. Khyber Medical College, Peshawar, Pakistan
  • 3. Institute of Integrative Biosciences, CECOS University
  • 4. Department of Bioengineering, University of Engineering and Applied Sciences, Swat, Pakistan
  • 5. Centre for Genomic Sciences, Rehman Medical Institute Peshawar, Pakistan

Description

Breast cancer comprises four subtypes: Luminal A, Luminal B, HER2-enriched, and Basal, each showing a distinct metastatic precedence to various organs, including the bones, lung, liver, and brain. Interactions between chemokines (cell-derived factors that cause directional migration of cells [1]) and their receptors may contribute to the organ-specific spread of the subtypes.

 

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Additional details

References

  • 1. Jin, Tian, et al. "Chemotaxis, Chemokine Receptors and Human Disease," Cytokine.
  • 2. Dalal, H., Dahlgren, M., Gladchuk, S., Brueffer, C., et al. "Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors," Sci Rep, 2022.
  • 3. Ho, X. D., Phung, P., Le, V. Q., Nguyen, V. H., et al. "Whole transcriptome analysis identifies differentially regulated networks between osteosarcoma and normal bone samples," Exp Biol Med (Maywood).