Published 2023
| Version v1
Poster
Open
Drug Repurposing for Head and Neck Squamous Cell Carcinoma (HNSCC) Using Protein Domain Interactions
Authors/Creators
- 1. Precision Medicine Lab (CECOS RMI)
- 2. Khyber Girls Medical College
- 3. Institute of Integrative Biosciences, CECOS University
- 4. Department of Bioengineering, University of Engineering and Applied Sciences, Swat, Pakistan
- 5. Centre for Genomic Sciences, Rehman Medical Institute Peshawar, Pakistan
Description
Head and Neck Squamous Cell Carcinoma (HNSCC) originates from squamous cells lining the mucosal surfaces of the head and neck region, affecting areas such as the oral cavity, oropharynx, nasopharynx, nasal cavity, paranasal sinuses, larynx, and hypopharynx [1]. Drug repurposing offers a cost-effective approach to identify new treatments by reutilizing existing drugs with established safety profiles [2]. Exploring protein domain interactions can uncover new insights into disease mechanisms and potential therapeutic targets [3].
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Additional details
References
- 1. Johnson, Daniel E., et al. "Head and Neck Squamous Cell Carcinoma." Nature Reviews Disease Primers, vol. 6, no. 1, Nov. 2020, pp. 1–22. www.nature.com
- 2. Pushpakom, Sudeep, et al. "Drug Repurposing: Progress, Challenges and Recommendations." Nature Reviews. Drug Discovery, vol. 18, no. 1, Jan. 2019, pp. 41–58. PubMed
- 3. Vincenzi, Marian, et al. "Protein Interaction Domains and Post-Translational Modifications: Structural Features and Drug Discovery Applications." Current Medicinal Chemistry, vol. 27, no. 37, Nov. 2020, pp. 6306–55. DOI.org
- 4. Aghiorghisesei, Ovidiu, et al. "The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns." Genes, vol. 13, no. 4, Apr. 2022, p. 594. www.mdpi.com