Published October 9, 2024
| Version v1.0
Dataset
Open
Orthrus: Towards Evolutionary and Functional RNA Foundation Models
Authors/Creators
Description
Orthrus is a mature RNA model for RNA property prediction. It uses a Mamba encoder backbone, a variant of state-space models specifically designed for long-sequence data, such as RNA.
Two versions of Orthrus are available:
- 4-track base version: Encodes the mRNA sequence with a simplified one-hot approach.
- 6-track large version: Adds biological context by including splice site indicators and coding sequence markers, which is crucial for accurate mRNA property prediction such as RNA half-life, ribosome load, and exon junction detection.
Files
appris_data_human.principal.txt
Files
(19.6 GB)
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4.1 GB | Download |
Additional details
Software
- Repository URL
- https://github.com/bowang-lab/Orthrus