EXREGMED (EXcellence in REGenerative MEDicine)

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Published May 8, 2024 | Version v1
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Continuous fabrication of braided composite nanofibrous surgical yarns using advanced AC electrospinning and braiding technology

Authors/Creators

  • 1. Technical University of Liberec

Description

Composite nanofibrous yarns (CNY), featuring a submicron electrospun sheath coated on a micro-scale core yarn have gained attention within the academic and industrial communities due to their unique structure. When braided, these CNYs hold great promise as next-generation surgical yarns. However, large-scale production of CNYs using conventional electrospinning techniques remains technologically challenging, and maintaining the integrity of the fibrous sheath during braiding presents further difficulties. Here, we propose a novel approach for continuously fabricating functional braided CNYs using collectorless alternating current (AC) electrospinning and braiding technology. Our approach utilized polycaprolactone-polylactic acid (PCL-PLA) blends and PCL-PLA with chlorhexidine (CHX) or triclosan (TRC) electrospun fibers for the sheath layer, while PLA micro-yarns acted as the core layer. Morphological analyses confirmed the successful fabrication of braided CNYs. Additionally, infrared spectroscopy validated the presence of CHX or TRC in the resulting yarns. The resulting braided CNYs exhibited excellent breaking force (29 N) and thermal stability (270 °C). Cytotoxicity and antibacterial assessments demonstrated that CHX-loaded braided CNYs could serve as biocompatible antibacterial surgical sutures. The proposed method offers a versatile approach for producing various functional braided CNYs applicable in tissue engineering scaffolds, filters, wearable electronics, and sensors.

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Additional details

Identifiers

DOI
10.1016/j.coco.2024.101932

Related works

Is published in
10.1016/j.coco.2024.101932 (DOI)

Funding

Ministry of Education Youth and Sports
Excellence in Regenerative Medicine CZ.02.01.01/00/22_008/0004562
Technical University of Liberec
Optimization and functionalization of suture material containing nanofibers for medical use SGS-2021-4007

Dates

Accepted
2024-05-07

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