Management of Postpartum Hemorrhage-Carbetocin Versus Methergin: A Comparative Study
Authors/Creators
- 1. Associate Professor, Department of OBG, CAIMS, Karimnagar
- 2. Postgraduate, Department of OBG, PIMS, Karimnagar
- 3. Professor, Department of OBG, CAIMS, Karimnagar
- 4. Postgraduate, Department of General Surgery, DY Patil Medical College, Pune
Description
Background: Postpartum haemorrhage (PPH) kills one woman every minute around the world, and it is still the leading cause of maternal death and morbidity. To limit the burden of PPH, early identification of risk factors, as well as effective prevention and management of PPH, are crucial. Carbetocin is a synthetic analogue of oxytocin with a half-life of up to 4 to 10 times that of oxytocin, making it a new medication for the prevention of uterine atony. Unlike oxytocin, it is administered as a single-dose injection rather than an infusion and can be administered intravenously or intramuscularly. Aim: The aim of our study was to examine the efficacy of carebtocin and combination oxytocin and methergine in avoiding postpartum haemorrhage in high-risk individuals after a normal vaginal delivery. Materials and Methods: This study was conducted between 01 July 2021 to 01 December 2021. In this study, 150 patients were included between 37 and 40 weeks of gestation with risk factors for developing PPH. In this study, the patients were divided into 2 equal groups namely group I which consisted of 75 pregnant women. These patients received a single dose of carbetocin 100 mg I.M. Group 2 consisted of 75 pregnant women. These pregnant women received oxytocin 5 I.U. I.M. combined with methergine 0.2 I.M. Results: Carbetocin was significantly more successful in reducing the time of the third stage of labour, reducing the amount of blood loss, and lowering both HB percent and hematocrit levels, all while having a significantly lower incidence of side effects. Conclusion: A single 100 mg IM dose of carbetocin may be more effective than 5 IU IM oxytocin mixed with 1 mL, 0.2 mg IM methylergonovine maleate (Methergine®) in reducing postpartum blood loss with a smaller drop in haemoglobin levels.
Abstract (English)
Background: Postpartum haemorrhage (PPH) kills one woman every minute around the world, and it is still the leading cause of maternal death and morbidity. To limit the burden of PPH, early identification of risk factors, as well as effective prevention and management of PPH, are crucial. Carbetocin is a synthetic analogue of oxytocin with a half-life of up to 4 to 10 times that of oxytocin, making it a new medication for the prevention of uterine atony. Unlike oxytocin, it is administered as a single-dose injection rather than an infusion and can be administered intravenously or intramuscularly. Aim: The aim of our study was to examine the efficacy of carebtocin and combination oxytocin and methergine in avoiding postpartum haemorrhage in high-risk individuals after a normal vaginal delivery. Materials and Methods: This study was conducted between 01 July 2021 to 01 December 2021. In this study, 150 patients were included between 37 and 40 weeks of gestation with risk factors for developing PPH. In this study, the patients were divided into 2 equal groups namely group I which consisted of 75 pregnant women. These patients received a single dose of carbetocin 100 mg I.M. Group 2 consisted of 75 pregnant women. These pregnant women received oxytocin 5 I.U. I.M. combined with methergine 0.2 I.M. Results: Carbetocin was significantly more successful in reducing the time of the third stage of labour, reducing the amount of blood loss, and lowering both HB percent and hematocrit levels, all while having a significantly lower incidence of side effects. Conclusion: A single 100 mg IM dose of carbetocin may be more effective than 5 IU IM oxytocin mixed with 1 mL, 0.2 mg IM methylergonovine maleate (Methergine®) in reducing postpartum blood loss with a smaller drop in haemoglobin levels.
Files
IJPCR,Vol14,Issue1,Article76.pdf
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Additional details
Dates
- Accepted
-
2022-01-31
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue1,Article76.pdf
- Development Status
- Active
References
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