Comparison of Nonlinear Dynamical Parameters in Newly Diagnosed Hypertensives and Normotensives Adults
Authors/Creators
- 1. Associate Professor, Dept. of Physiology, SMS Medical College, Jaipur
- 2. Associate Professor, Dept. of Anatomy, SMS Medical College, Jaipur
- 3. Assistant Professor, Dept. of Physiology, RVRS Medical college, Bhilwara
Description
Background: The cardiac autonomic modulations might be responsible for the pathogenesis of essential hypertension. Various measures of heart rate variability (HRV) are used to reveal autonomic tone. The present study used the Poincare plot to compare newly diagnosed hypertensives with normotensives. Methods: In this cross-sectional study, hypertensives (N=70) and normotensives (N=70) were compared using geometrical parameters of the Poincare plot. The study was conducted in the Department of Physiology, SMS Medical College and attached Hospital, Jaipur (Rajasthan, India), after approval from the Institutional Ethics Committee. The HRV was acquired using the standard protocol, and the SD1, SD2, and SD1/SD2 ratio were calculated using Kubois software. The groups were compared using the Mann-Whitney U test with statistical significance considered at 5%. Results: The age and gender showed no significant differences [p > 0.05]. The two groups were significantly differed in cardiovascular parameters including heart rate [W=4209; p <0.001], systolic blood pressure [W=4899.5; p <0.001] and diastolic blood pressure [W =4696.5; p <0.001].The Poincare parameters including SD1 [W=711.5; p <0.001], SD2 [W=1764; p = 0.004] and SD1/SD2 ratio [W =540; p<0.001] was significantly decreased in hypertensives as compared to normotensives. Conclusion: The present study endorsed Poincare analysis as an independent prognostic tool to predict autonomic dysfunction in newly diagnosed hypertensives.
Abstract (English)
Background: The cardiac autonomic modulations might be responsible for the pathogenesis of essential hypertension. Various measures of heart rate variability (HRV) are used to reveal autonomic tone. The present study used the Poincare plot to compare newly diagnosed hypertensives with normotensives. Methods: In this cross-sectional study, hypertensives (N=70) and normotensives (N=70) were compared using geometrical parameters of the Poincare plot. The study was conducted in the Department of Physiology, SMS Medical College and attached Hospital, Jaipur (Rajasthan, India), after approval from the Institutional Ethics Committee. The HRV was acquired using the standard protocol, and the SD1, SD2, and SD1/SD2 ratio were calculated using Kubois software. The groups were compared using the Mann-Whitney U test with statistical significance considered at 5%. Results: The age and gender showed no significant differences [p > 0.05]. The two groups were significantly differed in cardiovascular parameters including heart rate [W=4209; p <0.001], systolic blood pressure [W=4899.5; p <0.001] and diastolic blood pressure [W =4696.5; p <0.001].The Poincare parameters including SD1 [W=711.5; p <0.001], SD2 [W=1764; p = 0.004] and SD1/SD2 ratio [W =540; p<0.001] was significantly decreased in hypertensives as compared to normotensives. Conclusion: The present study endorsed Poincare analysis as an independent prognostic tool to predict autonomic dysfunction in newly diagnosed hypertensives.
Files
IJPCR,Vol14,Issue3,Article91.pdf
Files
(185.2 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:43465f9a2fa8638fd60299d95bcc2775
|
185.2 kB | Preview Download |
Additional details
Dates
- Accepted
-
2022-03-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue3,Article91.pdf
- Development Status
- Active
References
- 1. Chobanian A V., Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the Joint National Committee on Prevention,Detection, Evaluation, and Treatment of High Blood Pressure. Hypertens (Dallas, Tex 1979) [Internet]. 2003 Dec [cited 2022 Jun 27];42(6):1206– 52. Available from: https://pubmed. ncbi.nlm.nih.gov/14656957/ 2. Kumawat AK, Tak A, Gupta K, Kumar Gupta J. A Study of Time Domain Analysis and Poincare Plot Analysis of Heart Rate Variability in Newly Diagnosed Hypertensives. 3. KotchenTA. Hypertensive Vascular Disease. In: Harrison's Principles of Internal Medicine. 12th ed. New York: Tata McGraw Hill; p. 2042-59. 4. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology - PubMed [Internet]. [cited 2022 Jun 27]. Available from: https://pubmed.ncbi. nlm.nih.gov/8598068/ 5. Bian C, Qin C, Ma QDY, Shen Q. Modified permutation-entropy analysis of heartbeat dynamics. Phys Rev E - Stat Nonlinear, Soft Matter Phys. 2012 Feb 10;85(2). 6. Tak A. A study of frequency domain analysis of heart rate variability in newly diagnosed hypertensives. J Med Sci Clin Res [Internet]. 2019 Aug 16;7(8). Available from: http://jmscr. igmpublication.org/v7-i8/79 jmscr.pdf 7. Satti R, Abid NUH, Bottaro M, De Rui M, Garrido M, Rauofy MR, et al. The application of the extended Poincaré plot in the analysis of physiological variabilities. Front Physiol. 2019;10(FEB):116. 8. Brennan M, Palaniswami M, Kamen P. Do existing measures of Poincareé plot geometry reflect nonlinear features of heart rate variability? IEEE Trans Biomed Eng. 2001;48(11):1342–7. 9. JASP Team. JASP (Version 0.16.2.0)[Computer software] [Internet]. 2022. Available from: https: //jasp-stats.org/ 10. Khandoker AH, Karmakar C, Brennan M, Voss A, Palaniswami M. Poincaré plot methods for heart rate variability analysis. Poincaré Plot Methods Hear Rate Var Anal. 2013 Nov 1;9781461473:1–146. 11. Velusami D. Available Online through non linear analysis of heart rate variability using poincare plot ISSN: 0975-766X CODEN : IJPTFI Research Article. 2020;(September 2016 12. Karmakar CK, Khandoker AH, Voss A, Palaniswami M. Sensitivity of temporal heart rate variability in Poincaré plot to changes in parasympathetic nervous system activity. Biomed Eng Online. 2011 Mar 3;10. 13. Goit RK, Ansari AH. Reduced parasympathetic tone in newly diagnosed essential hypertension. Indian Heart J [Internet]. 2016 Mar 1 [cited 2022 Jun 28];68(2):153. Available from: /pmc/articles/PMC 4867020/ 14. Pushpanathan P, Trakroo M, Rp S, Madhavan C. Heart rate variability by Poincaré plot analysis in patients of essential hypertension and 12-week yoga therapy. 2015 [cited 2022 Jun 28]; Available from: http://www.njp pp.com 15. Darmal, D. I., Khan, A., Ahmad, D. S., & Gowani, A. Frequency of Type II Diabetes Mellitus in ST Segment Elevated MI patients presented to French Medical Institute for Mothers and Children: A Cross Section Study. Journal of Medical Research and Health Sciences, 2022:5(6), 2023– 2038.