Fast label-free live imaging reveals regulation of cancer cell endothelium adhesion by flow and CD44-HA interaction

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Fast label-free live imaging reveals regulation of cancer cell endothelium adhesion by flow and CD44-HA interaction

doi: https://doi.org/10.1101/2024.09.30.615654

Gautier Follain1,2, Sujan Ghimire2*, Joanna W Pylvänäinen2,3*, Monika Vaitkevičiūtė1,2,3, Diana Wurzinger2, Camilo Guzmán4, James RW Conway5, Michal Dibus1, Sanna Oikari6, Kirsi Rilla6, Marko Salmi3,7,8, Johanna Ivaska1,3,9-11#, Guillaume Jacquemet1,2,3,12#.

1. Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, FI

2. Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, FI-20520 Turku, FI

3. InFLAMES Research Flagship Center, University of Turku and Åbo Akademi University, 20520 Turku, FI.

4. Euro-BioImaging ERIC, Turku, FI

5. Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, FI.

6. Institute of Biomedicine, University of Eastern Finland, 70211 Kuopio, FI

7. Institute of Biomedicine, University of Turku, Turku, FI

8. MediCity Research Laboratory, University of Turku, Turku, FI

9. Department of Life Technologies, University of Turku, 20520 Turku, FI.

10. Western Finnish Cancer Center (FICAN West), University of Turku, 20520 Turku, FI. 

11. Foundation for the Finnish Cancer Institute, Tukholmankatu 8, 00014 Helsinki, FI

12. Turku Bioimaging, University of Turku and Åbo Akademi University, FI- 20520 Turku, FI