A Comparative Evaluation of Premedication with Oral Gabapentin and Pregabalin in Attenuation of Pressor Response to Endotracheal Intubation under General Anaesthesia
Authors/Creators
- 1. Junior Resident, Department of Anaesthesiology, Kempegowda Institute of Medical Sciences (KIMS), Bengaluru, Karnataka
- 2. Professor, Department of Anaesthesiology, Kempegowda Institute of Medical Sciences (KIMS), Bengaluru, Karnataka
- 3. Senior Resident, Department of Anaesthesiology, Kempegowda Institute of Medical Sciences (KIMS), Bengaluru, Karnataka
Description
Background: In this study we wanted to compare the effects of oral Pregabalin and Gabapentin in attenuating the hemodynamic response to laryngoscopy and intubation in relation to heart rate, blood pressure-systolic and diastolic and mean arterial pressure. Materials and Methods: Sixty patients belonging to ASA grade 1 and 2 were randomly divided into two groups of thirty each. Oral Gabapentin 600mg and oral Pregabalin 150 mg was given 1 hr prior to surgery. Both groups were premedicated with Glycopyrolate 0.005 mg/kg and Fentanyl 1.5μg/kg was given. They were induced with Thiopentone sodium 5 mg/kg and intubation was aided with Vecuronium 0.1 mg/kg.The hemodynamic parameters recorded were heart rate, systolic and diastolic blood pressure and the mean arterial pressure every minute upto 5 minutes and at 10 minutes, 15 minutes, 30 minutes and 45 minutes time interval in each group. Statistical analysis was done using Chi-square (χ2) test of significance and Student “t’’ test and P value obtained. Results: Both groups showed attenuation of stress response. Pregabalin and Gabapentin affected heart rate to same extent upto 5 minutes (p>0.05). In Gabapentin group, there was increase in SBP, DBP and MBP upto 3 minutes, after that it was maintained below the baseline. In Pregabalin group there was no rise in systolic and diastolic blood pressure and mean arterial blood pressure compared to the baseline from the 1st minute of intubation which is statistically significant (p<0.001). Conclusion: Both Pregabalin and Gabapentin attenuate the stress response to laryngoscopy and intubation. When both these drugs were compared. Pregabalin attenuated the stress response to laryngoscopy and intubation better than Gabapentin and afforded a good hemodynamic stability.
Abstract (English)
Background: In this study we wanted to compare the effects of oral Pregabalin and Gabapentin in attenuating the hemodynamic response to laryngoscopy and intubation in relation to heart rate, blood pressure-systolic and diastolic and mean arterial pressure. Materials and Methods: Sixty patients belonging to ASA grade 1 and 2 were randomly divided into two groups of thirty each. Oral Gabapentin 600mg and oral Pregabalin 150 mg was given 1 hr prior to surgery. Both groups were premedicated with Glycopyrolate 0.005 mg/kg and Fentanyl 1.5μg/kg was given. They were induced with Thiopentone sodium 5 mg/kg and intubation was aided with Vecuronium 0.1 mg/kg.The hemodynamic parameters recorded were heart rate, systolic and diastolic blood pressure and the mean arterial pressure every minute upto 5 minutes and at 10 minutes, 15 minutes, 30 minutes and 45 minutes time interval in each group. Statistical analysis was done using Chi-square (χ2) test of significance and Student “t’’ test and P value obtained. Results: Both groups showed attenuation of stress response. Pregabalin and Gabapentin affected heart rate to same extent upto 5 minutes (p>0.05). In Gabapentin group, there was increase in SBP, DBP and MBP upto 3 minutes, after that it was maintained below the baseline. In Pregabalin group there was no rise in systolic and diastolic blood pressure and mean arterial blood pressure compared to the baseline from the 1st minute of intubation which is statistically significant (p<0.001). Conclusion: Both Pregabalin and Gabapentin attenuate the stress response to laryngoscopy and intubation. When both these drugs were compared. Pregabalin attenuated the stress response to laryngoscopy and intubation better than Gabapentin and afforded a good hemodynamic stability.
Files
IJPCR,Vol14,Issue5,Article68.pdf
Additional details
Dates
- Accepted
-
2022-05-15
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/14/IJPCR,Vol14,Issue5,Article68.pdf
- Development Status
- Active
References
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