COMPARATIVE STUDY OF SOLUBILITY AND DISSOLUTION ENHANCEMENT OF LACIDIPINE USINGSYNTHETIC AND NATURAL SURFACTANTS

In modern era a major concern associated formulation development by using synthetic new chemical entitiesis theirpoor water solubility which poses problemsof low oral bioavailability. Lacidipine a antihypertensive drug, classified as BCA class II drug is one such example with low solubility and hence low oral bioavailability. In present work successfullyattempt has been made to carry out a comparative study of solubility and dissolution enhancements of Lacidipine using SLS as synthetic and saponine extracted from soya been as natural surfactants. At 1.5% of SLS and saponine solubility enhancement shown by Lacidipine in aqueous medium was 25.95 and 42.64mg/ml compared to 0.55mg/ml. Added advantage of saponine is it has lipid lowering capability. So a formulation developed using combination may show better management of hypertension.