FORMULATION AND EVALUATION TOPICAL GEL OF ONDANSETRON

Objective: This study aimed to formulate and evaluate a topical gel containing ondansetron, a potent antiemetic, to explore its potential as an alternative delivery system for managing nausea and vomiting.

Methods: Ondansetron topical gel was formulated using various gelling agents and excipients to optimize its physicochemical properties. The formulations were evaluated for gel consistency, pH, drug content, in vitro drug release.

Results: The developed topical gels exhibited suitable consistency and pH levels, with optimal drug content uniformity. In vitro release studies indicated a controlled release profile, supporting sustained drug delivery.

Conclusion: The ondansetron topical gel formulations were successfully developed, demonstrating desirable properties such as sustained release and minimal skin irritation. This alternative delivery system holds promise for improving patient compliance and comfort in the management of nausea and vomiting.

Keywords: Ondansetron Topical Gel , HPMC, Sodium Cmc and Carbopol-934