FORMULATION AND EVALUATION OF FLOATING TABLETS OF LOSARTAN POTASSIUM BY USING NATURAL POLYMERS

The aim of  present research work is to formulate and evaluate controlled release floating tablet of Losartan Potassium in view to enhance bioavailability and therapeutic action.The tablets were formulated by employing direct compression method.The granules were evaluated for flow properties. All the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. All the tablets were formulated using sodium bicarbonate as effervescent agent.  All the prepared formulations floated immediately after placing into the beaker and the floating was maintained more than 14 hrs. It was observed that the carbon dioxide generated from sodium bicarbonate in presence of dissolution medium (0.1N HCL) was trapped in the polymer gel matrix formed by the hydration of polymer which decreases the density(<1) and makes the tablet buoyant. The correlation coefficient values (r) revealed that the dissolution profiles followed  Zero order kinetics and the mechanism of drug release was governed by Peppas model. The n values are found to be more than 0.5 (n>0.5) indicted that the drug release was predominantly controlled by non fickian diffusion. Based on the release rate constant and % of drug release  the formulations prepared with Dry mushroom powder shown prolonged  retarding nature compared with the formulations prepared with Almond gum. Among all the formulations , F₃ formulation containing  drug and Dry mushroom powder in 1:1.5 ratio  was found to be optimized formulations.

Key words:Losartan Potassium , Dry mushroom powder,  Almond gum, Sodium  bicarbonate