Published September 16, 2024 | Version 0

Structural diversity-oriented synthesis

Authors/Creators

  • 1. Institute of Organic Synthesis
  • 1. Institute of Organic Synthesis
  • 2. orcid

Description

The DMP is focused on exploration of skeletal transformations of beta-caryophyllene, one of most accessible sesquiterpenes. This abundant natural product possesses cyclobutane and E-cyclononene fragments, which have an intrinsic aptitude to form other scaffolds under various reaction conditions. The aim of this DMP is to provide a scalable route to more exotic biologically active congeners of beta-caryophyllene (chlorinated hemiketals rumphellatins A-C and rumphellclovanes A-E). 

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