Precision Public Health: Leveraging Genomic and Biologic Data to Customize Interventions and Enhance Population Health Outcomes
Authors/Creators
- 1. Assistant Professor, Department of Community Medicine, Hi-Tech Medical College and Hospital, Bhubaneshwar, Odisha, India
Description
Background: Precision public health is an innovative approach that integrates genomic and biological data to tailor public health interventions to specific population subgroups. This method contrasts with traditional one-size-fits-all strategies, aiming to enhance the effectiveness of interventions and improve health outcomes. As genomic technologies become more accessible, there is growing interest in their application within public health settings. Aim: This study aims to evaluate the impact of leveraging genomic and biological data on customized health interventions and their effectiveness in a general outpatient department (OPD) setting. Methods: A cross-sectional study was conducted. A total of 500 participants were randomly selected from the OPD patient population. Data were collected from electronic health records, patient surveys, and genomic data. Statistical analysis was performed using SPSS version 23.0, with Chi-square tests, t-tests, ANOVA, and multivariate regression analyses to assess the association between genomic markers and health outcomes. Results: Participants with genomic risk markers showed significantly improved health outcomes compared to those without such markers (60% vs. 50%, p = 0.01). Age was also identified as a significant predictor, with younger participants more likely to experience better outcomes. The regression model explained 25% of the variance in health outcomes, highlighting the importance of genomic data in tailoring interventions. Conclusion: The study demonstrates the potential of integrating genomic data into public health strategies to enhance the effectiveness of interventions, particularly for individuals with genetic predispositions. The findings support the need for broader implementation of precision public health approaches to improve population health outcomes. Recommendations: Future research should explore the long-term impacts of genomic-driven interventions and address the ethical and logistical challenges of integrating precision public health into routine care.
Abstract (English)
Background: Precision public health is an innovative approach that integrates genomic and biological data to tailor public health interventions to specific population subgroups. This method contrasts with traditional one-size-fits-all strategies, aiming to enhance the effectiveness of interventions and improve health outcomes. As genomic technologies become more accessible, there is growing interest in their application within public health settings. Aim: This study aims to evaluate the impact of leveraging genomic and biological data on customized health interventions and their effectiveness in a general outpatient department (OPD) setting. Methods: A cross-sectional study was conducted. A total of 500 participants were randomly selected from the OPD patient population. Data were collected from electronic health records, patient surveys, and genomic data. Statistical analysis was performed using SPSS version 23.0, with Chi-square tests, t-tests, ANOVA, and multivariate regression analyses to assess the association between genomic markers and health outcomes. Results: Participants with genomic risk markers showed significantly improved health outcomes compared to those without such markers (60% vs. 50%, p = 0.01). Age was also identified as a significant predictor, with younger participants more likely to experience better outcomes. The regression model explained 25% of the variance in health outcomes, highlighting the importance of genomic data in tailoring interventions. Conclusion: The study demonstrates the potential of integrating genomic data into public health strategies to enhance the effectiveness of interventions, particularly for individuals with genetic predispositions. The findings support the need for broader implementation of precision public health approaches to improve population health outcomes. Recommendations: Future research should explore the long-term impacts of genomic-driven interventions and address the ethical and logistical challenges of integrating precision public health into routine care.
Files
IJPCR,Vol16,Issue8,Article274.pdf
Files
(291.7 kB)
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Additional details
Dates
- Accepted
-
2024-07-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue8,Article274.pdf
- Development Status
- Active
References
- 1. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015 Feb 2 6;372(9):793-5. 2. Manolio TA, Chisholm RL, Ozenberger B, et al. Implementing genomic medicine in the clinic: the future is here. Genet Med. 2019 May;21(5):972-981. 3. Ginsburg GS, Willard HF. Genomic and personalized medicine: foundations and applications. Transl Res. 2018 Jan;154(6):277- 287. 4. Juengst ET, Fishman JR, McGowan ML, Settersten RA Jr. Serving epigenetics before its time: lessons from the history of premature translational launches. Am J Bioeth. 2018;18 (6):22-31. 5. Khoury MJ, Bowen MS, Clyne M, et al. From public health genomics to precision public health: a 20-year journey. Genet Med. 2018 Jun;20(6):574-582. 6. Khoury M, Engelgau M, Chambers D, Mensah G. Beyond Public Health Genomics: Can Big Data and Predictive Analytics Deliver Precision Public Health? Public Health Genomics. 2019;21:244-250. 7. Mumtaz H, Saqib M, Jabeen S, Muneeb M, Mughal W, Sohail H, et al. Exploring alternative approaches to precision medicine through genomics and artificial intelligence – a systematic review. Front Med. 2023;10. 8. Khoury M, Holt K. The impact of genomics on precision public health: beyond the pandemic. Genome Med. 2021;13.