FORMULATION AND EVALUATION OF CONTROL RELEASED BUCCAL PATCHES OF PROPRANOLOL

Buccal drug delivery has been considered as an alternative to oral dosing for compounds subjected to degradation in the gastrointestinal tract or to hepatic first pass metabolism. Propranolol buccal patches were prepared by solvent casting technique using ethyl cellulose as baking membrane. . Propranolol buccal patches were prepared by using polymers like HPMC K15M,Guar gum, and karaya gum. Propylene glycol was used as plasticizer in the preparation of patches. Drug-excipients interaction studies (FTIR spectroscopy). The prepared patches will be evaluated for following parameter related to buccal drug delivery system like, a. Weight uniformity, b. Thickness. Folding endurance. Percentage swelling index,. Surface pH,of. Drug content estimation, g. Tensile strength,h. In- vitro drug release studies.In conclusion Propranolol buccal patches will be prepared to improve bioavailability and to avoid hepatic first pass metabolism. In all the cases the calculated standard deviation values are very low which they suggest that the prepared patches were uniform in weight. In all the cases the calculated standard deviation values are very low which suggest that, the prepared patches were uniform in thickness. From the result and conclusion of the research work we can summarize that propranolol can be delivered via buccal route.

 Keywords: Propranolol, HPMC, K15M, Gaur gum, karaya gum, propylene glycol and ethyl cellulose.