ACTIVATION OF ATP-DEPENDENT POTASSIUM CHANNELS AS A DIRECTION OF PHARMACOLOGICAL CORRECTION OF TOXIC KIDNEY DAMAGE

The relevance of research on the pharmacological regulation of the activity of ATP-dependent potassium (KATP) channels is driven by functional versatility of channels of this type. Their participation in body adaptation reactions, physiological and pathological processes stimulate the search and development of new drugs - modulators of KATP channels. In this experimental study, we focused on the renal action of the fluorine-containing activator of KATP channels flocalin and changes in the homeostatic processes of the kidneys under its influence. The obtained results indicate that the renal effects of flocalin in laboratory white rats with toxic kidney damage by sublimate are characterized by diuretic and antiproteinuric effects, a decrease in retention azotemia, an increase in the rate of glomerular filtration and reabsorption of sodium ions in the tubular part of the nephron. The research results indicate the participation of KATP channels in the development of toxic nephropathy and the protective effects of flocalin, both in the glomerular and tubular parts of the nephron.