The Impact of Topical Retinoid Therapy on Skin Aging in Patients with Photoaged Skin: A Cross-Sectional Study
Authors/Creators
- 1. Assistant Professor, Department of Pharmacology, Indira Medical College and Hospital, Thiruvallur, Tamil Nadu
- 2. Assistant Professor, Department of Dermatology, JR Medical College and Hospital, Avanampattu, Villupuram District, Tamilnadu
- 3. Former Research Scholar Department of Biochemistry, MGMCRI, Sri Balajividyapeeth, Puducherry
Description
Background: Photoaged skin, characterized by wrinkles, hyperpigmentation, and rough texture, poses a significant cosmetic concern. Topical retinoids are widely used for their anti-aging properties, but their efficacy and safety in diverse populations need further investigation. Objective: To evaluate the impact of topical retinoid therapy on skin aging in patients with photoaged skin. Methods: This cross-sectional study included 100 participants (mean age 55 years, range 40-70 years; 60% female) with photoaged skin. Participants applied topical tretinoin 0.05% cream once daily at bedtime for 6 months. Clinical outcomes assessed included wrinkle depth, skin texture, and hyperpigmentation. Subjective assessments were also conducted via a self-reported questionnaire. Statistical analysis was performed using paired t-tests. Results: Significant reductions in wrinkle depth (mean reduction 30%, 80% of participants, p < 0.01), skin texture improvement (mean improvement 35%, 75% of participants, p < 0.01), and hyperpigmentation reduction (mean reduction 25%, 70% of participants, p < 0.05) were observed. Subjective assessments indicated that 85% of participants perceived noticeable improvement, and 90% were satisfied with the treatment. Mild irritation and redness were reported by 40% of participants during the initial weeks, with no severe adverse effects. Pre-treatment and post-treatment scores showed significant improvements in all measured outcomes. Conclusion: Topical retinoid therapy significantly improves the clinical signs of aging in photoaged skin, with high patient satisfaction and minimal side effects. These findings support the use of topical retinoids as an effective treatment for aging skin. Further studies are recommended to validate these results and explore long-term benefits.
Abstract (English)
Background: Photoaged skin, characterized by wrinkles, hyperpigmentation, and rough texture, poses a significant cosmetic concern. Topical retinoids are widely used for their anti-aging properties, but their efficacy and safety in diverse populations need further investigation. Objective: To evaluate the impact of topical retinoid therapy on skin aging in patients with photoaged skin. Methods: This cross-sectional study included 100 participants (mean age 55 years, range 40-70 years; 60% female) with photoaged skin. Participants applied topical tretinoin 0.05% cream once daily at bedtime for 6 months. Clinical outcomes assessed included wrinkle depth, skin texture, and hyperpigmentation. Subjective assessments were also conducted via a self-reported questionnaire. Statistical analysis was performed using paired t-tests. Results: Significant reductions in wrinkle depth (mean reduction 30%, 80% of participants, p < 0.01), skin texture improvement (mean improvement 35%, 75% of participants, p < 0.01), and hyperpigmentation reduction (mean reduction 25%, 70% of participants, p < 0.05) were observed. Subjective assessments indicated that 85% of participants perceived noticeable improvement, and 90% were satisfied with the treatment. Mild irritation and redness were reported by 40% of participants during the initial weeks, with no severe adverse effects. Pre-treatment and post-treatment scores showed significant improvements in all measured outcomes. Conclusion: Topical retinoid therapy significantly improves the clinical signs of aging in photoaged skin, with high patient satisfaction and minimal side effects. These findings support the use of topical retinoids as an effective treatment for aging skin. Further studies are recommended to validate these results and explore long-term benefits.
Files
IJPCR,Vol16,Issue8,Article232.pdf
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Additional details
Dates
- Accepted
-
2024-07-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue8,Article232.pdf
- Development Status
- Active
References
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