Effectiveness of Dobutamine in Decreasing Acute MR in Acute Myocardial Infarction
Authors/Creators
- 1. Senior Resident, Department of Cardiology, KAPV Government Medical College and MGM Government Medical College, Trichy, Tamil Nadu, India
- 2. Assistant Professor, Department of Cardiology, KAPV Government Medical College and MGM Government Medical College, Trichy, Tamil Nadu, India
- 3. Professor and HOD, Department of Cardiology, KAPV Government Medical College and MGM Government Medical College, Trichy, Tamil Nadu, India
Description
Background: The Purpose of this study is to assess the Effectiveness of Dobutamine Intravenous Infusion in Acute Myocardial Infarction in Presence of acute Mitral Regurgitation. Methods: This prospective pre post interventional study was carried out among 50 Patients admitted to Coronary care unit of the Department of Cardiology, KAPV Government Medical College, Trichy with first episode of acute Myocardial infarction in Presence of Acute Mitral Regurgitation within 24 hrs of Symptom onset were recruited for the study. Patient’s Age and Gender and examine to identify the signs of Acute MR. Ecg and ECHO assessment of MR was performed as early as possible within 24 hrs of onset of symptoms. Results: In the present study the mean age of the Patients was 63.7±12.4 and 62% of them were Male and 38% were Female. Among the study Participants, 12% had Anterior Wall Myocardial Infarction and 40% had Inferior and 48% have Inferoposterior wall Myocardial Infarction. In Acute MI With Acute MR after Dobutamine Infusion there is an increase in hemodynamic parameters of Heart Rate (p value 0.001), Systolic BP (p value 0.002), Diastolic Blood Pressure (p Value 0.001), Spo2 (p value – 0.001), S4 (p Value – 0.001). In the Present study there was also strong association that after Dobutamine infusion in Acute MI with Acute MR there was significant improvement of MR Which was substantiated by the following Echocardiographic Parameters of Jet Length (p value 0.001), Jet Area (0.003), ERO (p value 0.001), Vena contracta (p value 0.002), Cradiac output (p value 0.004), Ejection Fraction ( p value 0.001 ), Regurgitant Volume (p value 0.002). Regurgitant fraction (0.001). Conclusions: The comprehensive echocardiographic evaluation of Acute MR in the context of acute myocardial infarction, after dobutamine infusion has resulted in favourable Haemodynamics and recuded mortality. From the results of the present study, it can be said that dobutamine is a positive inotropic agent that works also as “medical annuloplasty” since it not only increases forward cardiac output but also decreases mitral anular size and mitral regurgitant volume effectively.
Abstract (English)
Background: The Purpose of this study is to assess the Effectiveness of Dobutamine Intravenous Infusion in Acute Myocardial Infarction in Presence of acute Mitral Regurgitation. Methods: This prospective pre post interventional study was carried out among 50 Patients admitted to Coronary care unit of the Department of Cardiology, KAPV Government Medical College, Trichy with first episode of acute Myocardial infarction in Presence of Acute Mitral Regurgitation within 24 hrs of Symptom onset were recruited for the study. Patient’s Age and Gender and examine to identify the signs of Acute MR. Ecg and ECHO assessment of MR was performed as early as possible within 24 hrs of onset of symptoms. Results: In the present study the mean age of the Patients was 63.7±12.4 and 62% of them were Male and 38% were Female. Among the study Participants, 12% had Anterior Wall Myocardial Infarction and 40% had Inferior and 48% have Inferoposterior wall Myocardial Infarction. In Acute MI With Acute MR after Dobutamine Infusion there is an increase in hemodynamic parameters of Heart Rate (p value 0.001), Systolic BP (p value 0.002), Diastolic Blood Pressure (p Value 0.001), Spo2 (p value – 0.001), S4 (p Value – 0.001). In the Present study there was also strong association that after Dobutamine infusion in Acute MI with Acute MR there was significant improvement of MR Which was substantiated by the following Echocardiographic Parameters of Jet Length (p value 0.001), Jet Area (0.003), ERO (p value 0.001), Vena contracta (p value 0.002), Cradiac output (p value 0.004), Ejection Fraction ( p value 0.001 ), Regurgitant Volume (p value 0.002). Regurgitant fraction (0.001). Conclusions: The comprehensive echocardiographic evaluation of Acute MR in the context of acute myocardial infarction, after dobutamine infusion has resulted in favourable Haemodynamics and recuded mortality. From the results of the present study, it can be said that dobutamine is a positive inotropic agent that works also as “medical annuloplasty” since it not only increases forward cardiac output but also decreases mitral anular size and mitral regurgitant volume effectively.
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IJPCR,Vol16,Issue8,Article166.pdf
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Additional details
Dates
- Accepted
-
2024-07-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue8,Article166.pdf
- Development Status
- Active
References
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