Published 2006
| Version v1
Journal article
Restricted
Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1
Authors/Creators
- Keele, Brandon F.
- Heuverswyn, Fran Van
- Li, Yingying
- Bailes, Elizabeth
- Takehisa, Jun
- Santiago, Mario L.
- Bibollet-Ruche, Frederic
- Chen, Yalu
- Wain, Louise V.
- Liegeois, Florian
- Loul, Severin
- Ngole, Eitel Mpoudi
- Bienvenue, Yanga
- Delaporte, Eric
- Brookfield, John F. Y.
- Sharp, Paul M.
- Shaw, George M.
- Peeters, Martine
- Hahn, Beatrice H.
Description
(Uploaded by Plazi for the Bat Literature Project) Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.
The origins of HIV are traced to specific reservoir populations of wild chimpanzees.
The origins of HIV are traced to specific reservoir populations of wild chimpanzees.
Files
Restricted
The record is publicly accessible, but files are restricted. <a href="https://zenodo.org/account/settings/login?next=https://zenodo.org/records/13537077">Log in</a> to check if you have access.
Additional details
Identifiers
- URL
- hash://md5/ca6b5e4fbf5f49546febb5f3f381e8bb
- URN
- urn:lsid:zotero.org:groups:5435545:items:4UAK6JQE
- DOI
- 10.1126/science.1126531
Biodiversity
- Kingdom
- Animalia
- Phylum
- Chordata
- Class
- Mammalia
- Order
- Chiroptera