Published 1997
| Version v1
Journal article
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Immunologic responses to vaccinia vaccines administered by different parenteral routes.
Authors/Creators
Description
(Uploaded by Plazi for the Bat Literature Project) To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification. Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions. Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses.
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Additional details
Identifiers
- URL
- hash://md5/8c4b6a23d632042fcfb011392b9414e0
- URN
- urn:lsid:zotero.org:groups:5435545:items:NMBVWIWH
- DOI
- 10.1086/513968
Biodiversity
- Kingdom
- Animalia
- Phylum
- Chordata
- Class
- Mammalia
- Order
- Chiroptera