Published 2020
| Version v1
Journal article
Restricted
Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa
Authors/Creators
- Amman, Brian R.
- Bird, Brian H.
- Bakarr, Ibrahim A.
- Bangura, James
- Schuh, Amy J.
- Johnny, Jonathan
- Sealy, Tara K.
- Conteh, Immah
- Koroma, Alusine H.
- Foday, Ibrahim
- Amara, Emmanuel
- Bangura, Abdulai A.
- Gbakima, Aiah A.
- Tremeau-Bravard, Alexandre
- Belaganahalli, Manjunatha
- Dhanota, Jasjeet
- Chow, Andrew
- Ontiveros, Victoria
- Gibson, Alexandra
- Turay, Joseph
- Patel, Ketan
- Graziano, James
- Bangura, Camilla
- Kamanda, Emmanuel S.
- Osborne, Augustus
- Saidu, Emmanuel
- Musa, Jonathan
- Bangura, Doris
- Williams, Samuel Maxwell Tom
- Wadsworth, Richard
- Turay, Mohamed
- Edwin, Lavalie
- Mereweather-Thompson, Vanessa
- Kargbo, Dickson
- Bairoh, Fatmata V.
- Kanu, Marilyn
- Robert, Willie
- Lungai, Victor
- Guetiya Wadoum, Raoul Emeric
- Coomber, Moinya
- Kanu, Osman
- Jambai, Amara
- Kamara, Sorie M.
- Taboy, Celine H.
- Singh, Tushar
- Mazet, Jonna A. K.
- Nichol, Stuart T.
- Goldstein, Tracey
- Towner, Jonathan S.
- Lebbie, Aiah
Description
(Uploaded by Plazi for the Bat Literature Project) Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats.
Files
Restricted
The record is publicly accessible, but files are restricted. Log in to check if you have access.
Additional details
Identifiers
- URL
- hash://md5/bc720db545bdb9290c1946a8789db398
- URN
- urn:lsid:zotero.org:groups:5435545:items:9CDTLPWX
- DOI
- 10.1038/s41467-020-14327-8
Biodiversity
- Kingdom
- Animalia
- Phylum
- Chordata
- Class
- Mammalia
- Order
- Chiroptera