Effect of Noon Chai (Kashmiri Namkeen Tea) on the Microanatomy of Esophagus in Albino Rats: A Randomised Controlled Trial Study
Authors/Creators
- 1. Assistant Professor, Government Medical College Baramulla, Kashmir, India
- 2. Senior Resident, Department of Anatomy, Government Medical College Baramulla, Kashmir, India
- 3. Associate Professor, Department of Anatomy Government Medical College Srinagar, Kashmir, India
- 4. Professor, Department of Pathology, Government Medical College Srinagar, Kashmir, India
Description
Background: The present Randomized Controlled Trial (RCT) was conducted in the Postgraduate Department of Anatomy, Government Medical College Srinagar after taking ethical clearance from Institutional Ethical Committee. Materials and Methods: Fourteen albino rats weighing on an average 150 grams were taken from the animal house of Govt. Medical College Srinagar for the present study. These animals were randomly divided into 6 groups with 7 rats in each group. All groups of rats were kept under uniform husbandry condition in iron cages separately in groups. The processes of administration of these ingredients were continued for 36 weeks. The animals were sacrificed in six sittings with duration of 6 weeks between each sitting at 6th, 12th, 18th, 24th, 30th, & 36th week. Results: Kashmiri Namkeen Tea extract mixed with sodium chloride, and sodium bicarbonate caused premalignant changes in esophageal mucosa in the form of inflammation, Keratinsation, mucosal erosions, mucosal bleeding. These histopathological changes started to appear at 6th week and become more marked with further exposure in a duration dependent manner. Conclusion: Kashmiri Namkeen tea is carcinogenic; it produces premalignant changes in esophagus of Albino rats when exposure exceeds 6 weeks in a duration dependent manner.
Abstract (English)
Background: The present Randomized Controlled Trial (RCT) was conducted in the Postgraduate Department of Anatomy, Government Medical College Srinagar after taking ethical clearance from Institutional Ethical Committee. Materials and Methods: Fourteen albino rats weighing on an average 150 grams were taken from the animal house of Govt. Medical College Srinagar for the present study. These animals were randomly divided into 6 groups with 7 rats in each group. All groups of rats were kept under uniform husbandry condition in iron cages separately in groups. The processes of administration of these ingredients were continued for 36 weeks. The animals were sacrificed in six sittings with duration of 6 weeks between each sitting at 6th, 12th, 18th, 24th, 30th, & 36th week. Results: Kashmiri Namkeen Tea extract mixed with sodium chloride, and sodium bicarbonate caused premalignant changes in esophageal mucosa in the form of inflammation, Keratinsation, mucosal erosions, mucosal bleeding. These histopathological changes started to appear at 6th week and become more marked with further exposure in a duration dependent manner. Conclusion: Kashmiri Namkeen tea is carcinogenic; it produces premalignant changes in esophagus of Albino rats when exposure exceeds 6 weeks in a duration dependent manner.
Files
IJPCR,Vol16,Issue8,Article40.pdf
Files
(1.2 MB)
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Additional details
Dates
- Accepted
-
2024-07-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue8,Article40.pdf
- Development Status
- Active
References
- 1. Razdan V. A study of Kashmiri loves for the tea: History Tea: Search Kashmir in the bits and pieces: 2015; 1-3. 2. Saad R, Asmani F, Poornima, Khan J, Kaleemullah M, Al-dahlli S, Kazi H and Teo B .Influence of Geographical location on the antioxidant activity of green tea: 15.06.2016; 2700BC.Available from url: http://dx.org/10.18782/2320-7051.2315. 3. Mir MM, Dar NA. Esophageal CA in Kashmir India: anenigma for the researchers: International Journal of Health Science: 2009; 3(1): 71-85. 4. Rohan. How salt tea causes cancer January 2019; Available aturl:www.corehealths.com 5. Dar NA, Bhat GA, Shah IA, Iqbal B, Rafiq R, Nabi S, Lone MM, Islami F, Boffetta P. salt teaconsumption and esophageal cancer: a possible role of alkaline beverages in esophageal carcinogenesis: International Journal of Cancer 2015 March 15; 136. 6. Wani I, Parray FQ, Wani RA, Naqash SH, Wani KA, Malik AA, Choudri NA. Noon Chai and gastric cancer in Kashmir valley: Department of General Surgery, SKIMS, Srinagar, Kashmir 2014; available aturl:10.5348/ijcri2013-03-280-RA-1 7. Nagini S. Etiology of gastric cancer is multifactorial included by both dietary and nondietary factors: World Journal of Gastrointestinal Oncology. 2012; 15:4(7):156-69. 8. Khuroo MS, Zargar SA, Mahajan R, Banday MA. The epidemiology of esophageal cancer in Kashmir and special personal and dietary habits among Kashmiries:Gut. 1992 Jan; 33(1):11- 5. 9. Hu J, Nyren O, Wolk A and Bergstrom R. Risk factors for esophageal cancer in northeast China: International Journal of Cancer: 1994; 57:38-46. 10. Ishikawa A, Kuriyama S, Tsubono Y and Fukao A. Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men. Journal of Epidemiology, 2006; 16:185-192. 11. Inoue M, Tajima K, Hirose K, Hamajima N. Tea and coffee consumption and the risk of digestive tract cancers: Data from a comparative case–referent study in Japan: Cancer Causes and Control 1998;9: 209-216. 12. Charnley G, Tannenbanm SR. Flow cytometric analysis of the effect of Sodium chloride on gastric cancer risk in the rats: Cancer Res. 1985 Nov; 45(11 Pt 2):5608-16. 13. Fukushima, S. Co-carcinogenic Effects of NaHCO3 on O-phenyl phenol-induced Rat Bladder Carcinogenesis. Carcinogenesis, 1989; 10 (9): 1635-1640. 14. Sloup V, Jankovska I, Nechybova S, Perinkova P, Langrova I Czech. Roasting wheat, barley or green gram reduces phytic acid by about 40 percent: 2017; https://available at url.org/10.10 17/S0007114575000293Volume 48: Issue 1.