DrosophilaMuscleFunction: Revised Submission to Scientific Reports

This repository version corresponds to the bioRxiv preprint:

Hatfield I, Harvey I, Yates, ER, Redd, JR, Reiter LT, Bridges D (2014) The role of TORC1 in muscle development in Drosophila. bioRxiv. doi:10.1101/010991.

http://dx.doi.org/10.1101/010991

This version addressed the reviewer comments from the first round of submission. The relevant documents are here

• Reviewer Comments: SREP Reviews
• Response to Reviewers: SREP Response
• Updated Manuscript: Manuscript

Relevant Changes

• Added data regarding the effects of Mhc-GAL4 driven knockdown. This potentially late-acting driver had no effects on birth rates or climibing, but did have deleterious effects on the lifespan of the animals. This was done primarily in #19 and #18 .
• Tested role of fusion and expression of Myh proteins with rapamycin treatment. This was done primarily in #19 and #15
• Evaluated protein stability of MyoD. We found that MyoD proteinwas degraded quickly with rapamycin treatment, but that the mRNA was unaffected. This was done in issue #16
• Several other minor clarifications were also made in issue #17 and #14