Study of Lactate, Lactate Albumin Ratio (LAR), Procalcitonin (PCT) and Immature Platelet Fraction (IPF) as A Marker of Severity in Patients with Sepsis Having MAP >65mmhg and MAP <65mmhg in Tertiary Care Hospital
Authors/Creators
- 1. Resident Doctor, Department of General Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, India
- 2. Assistant Professor, Department of General Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, India
- 3. Resident of Physiotherapy, JNU Medical College, Jaipur, India
- 4. Principal Specialist, Ex Head of Department of Anaesthesiology Govt. Hospital Chittorgarh
- 5. Principal Specialist, Ex Head of Department of Obstetrics and Gynaecology Govt. Hospital Chittorgarh
Description
Aim: To assess the association of Lactate, Lactate Albumin Ratio, Procalcitonin and Immature Platelet Fraction on admission as markers of severity in sepsis patients. Objectives: (1) To assess Lactate / Albumin Ratio (LAR) in patients with sepsis. (2) To assess Lactate value in patients with sepsis. (3) To assess Procalcitonin (PCT) value in patients with sepsis. (4) To assess Immature Platelet Function (IPF) value in patients with sepsis. (4) To compare Lactate, LAR, PCT and IPF with MAP >65mmhg and MAP <65mmhg at tertiary care hospital in patients with sepsis for prognostication. Material and Methods: Hospital based Observational Cross-Sectional Study was conducted at Mahatma Gandhi Hospital, Jaipur between September 2022 to December 2023. Data of 180 patients was collected according to inclusion criteria. Sepsis biomarkers that is Lactate, LAR, IPF, PCT were calculated and were compared with MAP >65mmhg and MAP <65mmhg at tertiary care hospital in patients with sepsis for prognostication. Result: Procalcitonin emerges as a robust biomarker for stratifying infection severity and prognosis in sepsis patients across different MAP categories, underscoring its potential clinical utility. The findings highlight the importance of integrating multiple biomarkers and clinical parameters to enhance prognostic accuracy and guide therapeutic decisions tailored to individual patient needs in critical care settings. Conclusion: In our study MAP scores are significantly associated with Procalcitonin levels. Furthermore, the observed relationships between MAP scores, and Procalcitonin underscore the pivotal influence of hemodynamic status on metabolic responses and patient prognoses. These findings collectively underscore the importance of integrating comprehensive clinical and biochemical assessments to refine management strategies and enhance patient outcomes in cases of severe septic conditions.
Abstract (English)
Aim: To assess the association of Lactate, Lactate Albumin Ratio, Procalcitonin and Immature Platelet Fraction on admission as markers of severity in sepsis patients. Objectives: (1) To assess Lactate / Albumin Ratio (LAR) in patients with sepsis. (2) To assess Lactate value in patients with sepsis. (3) To assess Procalcitonin (PCT) value in patients with sepsis. (4) To assess Immature Platelet Function (IPF) value in patients with sepsis. (4) To compare Lactate, LAR, PCT and IPF with MAP >65mmhg and MAP <65mmhg at tertiary care hospital in patients with sepsis for prognostication. Material and Methods: Hospital based Observational Cross-Sectional Study was conducted at Mahatma Gandhi Hospital, Jaipur between September 2022 to December 2023. Data of 180 patients was collected according to inclusion criteria. Sepsis biomarkers that is Lactate, LAR, IPF, PCT were calculated and were compared with MAP >65mmhg and MAP <65mmhg at tertiary care hospital in patients with sepsis for prognostication. Result: Procalcitonin emerges as a robust biomarker for stratifying infection severity and prognosis in sepsis patients across different MAP categories, underscoring its potential clinical utility. The findings highlight the importance of integrating multiple biomarkers and clinical parameters to enhance prognostic accuracy and guide therapeutic decisions tailored to individual patient needs in critical care settings. Conclusion: In our study MAP scores are significantly associated with Procalcitonin levels. Furthermore, the observed relationships between MAP scores, and Procalcitonin underscore the pivotal influence of hemodynamic status on metabolic responses and patient prognoses. These findings collectively underscore the importance of integrating comprehensive clinical and biochemical assessments to refine management strategies and enhance patient outcomes in cases of severe septic conditions.
Files
IJPCR,Vol16,Issue7,Article274.pdf
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Additional details
Dates
- Accepted
-
2024-06-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article274.pdf
- Development Status
- Active
References
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