Formulation and Evaluation of Medicated Nail Lacquer for the Treatment of Onychomycosis
Authors/Creators
- 1. 1Shri D. D. Vispute College of Pharmacy and Research Center Devad-Vichumbe, New Panvel - 410206.
Contributors
- 1. 1Shri D. D. Vispute College of Pharmacy and Research Center Devad-Vichumbe, New Panvel - 410206.
Description
Abstract
Aims: The objective of the research work was to study about medicated antifungal nail lacquer for the treatment of Onychomycosis. Medicated nail lacquers generally act on a principle that it will form a film on the application surface from which the drug is released at a controlled rate for an extended period. Methods: The purpose of the investigation was to formulate and evaluate the Luliconazole nail lacquer as an ungual drug delivery system for the treatment of onychomycosis. Luliconazole an antifungal class of a drug was chosen along with Eudragit RS-100, Ethyl cellulose, Butyl acetate, Urea, Dibutyl phthalate, Methanol. As an excipient Eudragit RS 100 and Ethyl cellulose was used as sustained drug release polymer. Results: Formulation of nail lacquer done with taking different % of excipients. Further, these lacquers were compared for drying time, nonvolatile content drug content, drug diffusion and anti -microbial studies. Out of all 5 formulations F2 was considered as the optimized formulation. The stability studies show that the formulation is stable at 40 C for 15 days. F2 Formulation showed 98.5% drug content and 45 mm zone of inhibition which is greater compared to other formulations. So, a good therapeutic outcome can be expected. Microbial study results proved that the formulations are sensitive to the Candida albicans. Conclusion: So, from the above studies it can be concluded that an nail lacquer can be a better tool for ungal drug delivery system for the treatment of nail infection, onychomycosis.
Keywords
Medicated nail lacquers, onychomycosis, Luliconazole, ungual drug delivery system.
Files
26-34-Formulation-Diptee Marchande-3038027683.pdf
Files
(593.5 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:4e854bf3336d8cc77aedf77cf8387203
|
593.5 kB | Preview Download |
Additional details
References
- (1) V, V. K.; Chandran, S. C.; Rose Augusthy, A.; Rose Kuriakose, M. British biomedical bulletin Original Formulation and Evaluation of an Antifungal Nail Lacquer for Onychomycosis; 2014. (2) Pattanaik, S.; Thakur, P.; Guleria, M.; Tripathy, S.; Imran Ali, S.; Chhetri, J.; Talukdar, P.; Ranjan Rai, A.; Kumar, N.; Sudhakar, K. Topical Drug Delivery of Antimicrobial Agent Using Modern Technique to Treat Various Nail Infection. (3) Selvaraj, V.; Senthil, T.; Anilkumar, K.; Jawahar, N.; Venkatachalam, S. Medicated Lacquer Formulation for the Treatment of Nail Psoriasis. Res J Pharm Technol 2021, 14 (9), 5051– 5058. https://doi.org /10.52711/0974-360X.2021.00881. (4) Top 10 Most Common Nail Diseases & Disorders. ProMed 2022. (5) Kumar, T. P. Formulation and evaluation of bilayer nail lacquer containing antifungal drug for the treatment of onychomycosis .2022. https://doi.org/10.20959/wjpps20207-16662. (6) Dhamoon, R. K.; Goyal, R. K.; Popli, H.; Gupta, M. Luliconazole-Loaded Thermosensitive Hydrogel as Aqueous Based Nail Lacquer for the Treatment of Onychomycosis. Drug Deliv Lett , 9 (4), 321–329,2019 (7) Masumoto, A.; Takagi, M.; Sugiura, K.; Matsuda, Y.; Nakamura, S.; Tatsumi, Y. A Novel Method for Predicting the Efficacy of Topical Drugs on Onychomycosis: A Comparison of Efinaconazole and Luliconazole. Journal of Medical Mycology , 32 (3),2022 (8) Supriya Shrihari, S.; Hargovind, S.; Milind, P. K. Sustained Release Nail Lacquer Formulation Containing Combination of Luliconazole and Methyl Salicylate for the Treatment of Onychomycosis. (9) Manavalan, R.; Abraham Theodore, E.; Venkata Narayanan, R. Formulation and Evaluation Of A Medicated Nail Lacquer For The Treatment Of Onychomycosis. International Journal of Research in Pharmaceutical and Nano sciences, 5 (4), 201–211,2016. (10) Piraccini, B. M.; Alessandrini, A. Onychomycosis: A Review. Journal of Fungi. MDPI AG June 1, pp 30–43,2015. (11) Manavalan, M. R.; Pharm. Formulation and evaluation of a medicated nail lacquer for the treatment of onychomycosis. (12) Gregoriou, S.; Kyriazopoulou, M.; Tsiogka, A.; Rigopoulos, D. Novel and Investigational Treatments for Onychomycosis. Journal of Fungi. MDPI October 1, 2022. https://doi.org/10.3390/jof8101079. (13) Monti, D.; Tampucci, S.; Paganini, V.; Burgalassi, S.; Chetoni, P.; Galván, J.; Celandroni, F.; Ghelardi, E. Ciclopirox Hydroxypropyl Chitosan (CPX‐HPCH) Nail Lacquer and Breathable Cosmetic Nail Polish: In Vitro Evaluation of Drug Transungual Permeation Following the Combined Application. Life, 12 (6), 2022. (14) Puri, V.; Savla, R.; Chen, K.; Robinson, K.; Virani, A.; Michniak-Kohn, B. Antifungal Nail Lacquer for Enhanced Transungual Delivery of Econazole Nitrate. Pharmaceutics, 14 (10), 2204,2022 (15) Maria Piraccini Matilde Iorizzo André Lencastre Pietro Nenoff Dimitris Rigopoulos, B.; Piraccini, B. M.; Iorizzo, M.; Lencastre, A.; Rigopoulos, D. Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer: A Review of Its Use in Onychomycosis. Dermatol Ther (Heidelb) 10. (16) Veiga, F. F.; Gadelha, M. C.; da Silva, M. R. T.; Costa, M. I.; Kischkel, B.; de Castro-Hoshino, L. v.; Sato, F.; Baesso, M. L.; Voidaleski, M. F.; Vasconcellos-Pontello, V.; Vicente, V. A.; Bruschi, M. L.; Negri, M.; Svidzinski, T. I. E. Propolis Extract for Onychomycosis Topical Treatment: From Bench to Clinic. Front Microbiol , 9 (APR),2018. (17) Deepak Singh Bisht et Al., Formulation and Evaluation of Medicated Nail Lacquer. (18) Yadav, K. A Review Article on Anti-Fungal Nail Lacquer Using Treatment of Onychomycosis. International Journal of Scientific and Research Publications (IJSRP), 9 (4), p8848, 2019. (19) Pharmaceutics, I.; Manisha Bhagwan, M.; Pharm, R. B.; Kulkarni, A. S.; Pharm, M. "Formulation And Evaluation Of Nail Lacquer Containing Antifungal Drug" Master Of Pharmacy, Research Guide.