Published August 31, 2018 | Version v1
Journal article Open

Cross-Genetic Determination of Maternal and Neonatal Immune Mediators During Pregnancy

Authors/Creators

  • 1. Department of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America
  • 2. Divison of Research, Kaiser Permanente Northern California, Oakland, California, United States of America
  • 3. Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
  • 4. Division of Environmental and Occupational Disease Control, California Department of Public Health, Richmond, California, United States of America
  • 5. Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America

Description

We report here the summary statistics for the first large scale maternal and fetal genetic study of maternal mid-pregnancy and neonatal levels of 22 and 42 soluble immune mediators, respectively. We aimed to utilize genetic data to assess the role of maternal genetics in the maternal immune system during pregnancy, the role of fetal genetics in infant immune system at birth, influence of maternal genetics on infant immune status, and the role of fetal genetics on maternal immune status during pregnancy.  We performed an ancestry-combined GW SNP-based heritability analyses and GW association studies of 64 immune mediators in both mothers and neonates. 

Table1.csv.gz Summary statistics for each maternal cytokine and chemokine GWAS with maternal genetics. 

Table2.csv.gz Summary statistics for each neonatal cytokine and chemokine GWAS with fetal genetics.

Table3.csv.gz Summary statistics for each neonatal cytokine and chemokine GWAS with maternal genetics. 

Table4.csv.gz. Summary statistics for each maternal cytokine and chemokine GWAS with fetal genetics.

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