Effect of Gurmar (Gymnema sylvestre) Leaf Powder on Glycemic Control in Type 2 Diabetes Mellitus
Authors/Creators
- 1. Ph.D Scholar, Department of Physiology, S.P. Medical College, Bikaner, Rajasthan, India
- 2. Senior Professor and Head, Department of Physiology, S.P. Medical College, Bikaner, Rajasthan, India
- 3. Associate Professor, Department of Physiology, Govt. Medical College, Sri Ganganagar, Rajasthan, India
Description
Introduction: Diabetes mellitus (DM) is an endocrine disorder characterized by chronic hyperglycemia. Managing DM without side effects remains a challenge, drawing researchers to explore plant-based products. Some studies have found that the leaves of Gymnema sylvestre possess anti-diabetic, anti-obesity, anti-sweetener, anti-inflammatory, and antioxidant properties, which are attributed to saponins, glycosides, and flavonoids. Therefore, further investigation into its benefits is warranted. Aim and Objectives: This research aimed to assess the antidiabeticeffect of Gymnema sylvestre in patients with type 2 diabetes. Materials and Methods: Two hundred patients with type 2 DM were randomly divided into two groups. Group I (n = 100) received a placebo powder, while Group II (n = 100) was supplemented with 6 g/day of gurmar leaf powder. The patients continued taking their anti-diabetic medications as before, and patients were blinded to their treatment allocation. Fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c) levels were recorded at baseline and after 3 months. Results: In Group I FBS decreased non-significantly from 190.67 ± 59.53 mg/dl to 184.59 ± 57.46 mg/dl whereas in Group II FBS reduced significantly from 189.93 ± 55.21 mg/dl to 157.77 ± 44.84 mg/dl after 3 month of gurmar intervention. Similarly, HbA1c in Group II reduced significantly from 8.65 ± 1.16% to 7.70 ± 1.09% after 3 months (P < 0.05), while a non-significant decrease from 8.51 ± 1.04% to 8.33 ± 1.08% was recorded in Group I. Conclusion: The supplementation of Gurmar leaf powder significantly improves glycemic control in individuals with type 2 diabetes mellitus.
Abstract (English)
Introduction: Diabetes mellitus (DM) is an endocrine disorder characterized by chronic hyperglycemia. Managing DM without side effects remains a challenge, drawing researchers to explore plant-based products. Some studies have found that the leaves of Gymnema sylvestre possess anti-diabetic, anti-obesity, anti-sweetener, anti-inflammatory, and antioxidant properties, which are attributed to saponins, glycosides, and flavonoids. Therefore, further investigation into its benefits is warranted. Aim and Objectives: This research aimed to assess the antidiabeticeffect of Gymnema sylvestre in patients with type 2 diabetes. Materials and Methods: Two hundred patients with type 2 DM were randomly divided into two groups. Group I (n = 100) received a placebo powder, while Group II (n = 100) was supplemented with 6 g/day of gurmar leaf powder. The patients continued taking their anti-diabetic medications as before, and patients were blinded to their treatment allocation. Fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c) levels were recorded at baseline and after 3 months. Results: In Group I FBS decreased non-significantly from 190.67 ± 59.53 mg/dl to 184.59 ± 57.46 mg/dl whereas in Group II FBS reduced significantly from 189.93 ± 55.21 mg/dl to 157.77 ± 44.84 mg/dl after 3 month of gurmar intervention. Similarly, HbA1c in Group II reduced significantly from 8.65 ± 1.16% to 7.70 ± 1.09% after 3 months (P < 0.05), while a non-significant decrease from 8.51 ± 1.04% to 8.33 ± 1.08% was recorded in Group I. Conclusion: The supplementation of Gurmar leaf powder significantly improves glycemic control in individuals with type 2 diabetes mellitus.
Files
IJPCR,Vol16,Issue7,Article118.pdf
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Additional details
Dates
- Accepted
-
2024-06-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue7,Article118.pdf
- Development Status
- Active
References
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