Non HDL Cholesterol as a Better Predictor of Coronary Heart Disease Risk in Obesity
Authors/Creators
- 1. Associate Professor, Department of Biochemistry, Govt. Villupuram Medical College, Villupuram
- 2. Associate Professor, Department of Biochemistry, Govt. Vellore Medical College, Vellore
- 3. Associate Professor, Department of Biochemistry, Govt ESIC Medical College, Coimbatore
- 4. Associate Professor, Department of Biochemistry, Govt. Coimbatore Medical College, Coimbatore
Description
Background: Elevated triglyceride (TG), low density lipoprotein(LDL-C) and lower high-density lipoprotein cholesterol (HDL-C) levels found in metabolic syndrome , type 2 diabetes and Obesity are commonly associated with coronary heart disease (CHD). Non-HDL-C (total cholesterol minus HDL-C) provides a measure of the overall cholesterol content of atherogenic lipoproteins, and hence predicts the potential risk conferred by elevated levels of atherogenic TG-rich remnants. Aim: This study aims to assess whether there is increases risk of CHD in Obese individuals with elevation of non HDL cholesterol and its correlation with LDL cholesterol. Settings and Design: This is an observational case control study with 307 participants. Materials and Methods: 158 cases of CHD cases and 149 controls were recruited for this study.3mL of venous plasma was collected and analysed for lipid profile, glucose. Non-HDL cholesterol was calculated from cholesterol and HDL values. Obesity was identified by calculation of BMI. Statistical Analysis: The analysis of the results was done using unpaired ‘t’ test, Pearson correlation. Results: Non HDL cholesterol is increased significantly in CHD patients with obesity than controls. Conclusion: Non HDL cholesterol is a better predictor of CHD and is comparable to LDL cholesterol in Obese individuals.
Abstract (English)
Background: Elevated triglyceride (TG), low density lipoprotein(LDL-C) and lower high-density lipoprotein cholesterol (HDL-C) levels found in metabolic syndrome , type 2 diabetes and Obesity are commonly associated with coronary heart disease (CHD). Non-HDL-C (total cholesterol minus HDL-C) provides a measure of the overall cholesterol content of atherogenic lipoproteins, and hence predicts the potential risk conferred by elevated levels of atherogenic TG-rich remnants. Aim: This study aims to assess whether there is increases risk of CHD in Obese individuals with elevation of non HDL cholesterol and its correlation with LDL cholesterol. Settings and Design: This is an observational case control study with 307 participants. Materials and Methods: 158 cases of CHD cases and 149 controls were recruited for this study.3mL of venous plasma was collected and analysed for lipid profile, glucose. Non-HDL cholesterol was calculated from cholesterol and HDL values. Obesity was identified by calculation of BMI. Statistical Analysis: The analysis of the results was done using unpaired ‘t’ test, Pearson correlation. Results: Non HDL cholesterol is increased significantly in CHD patients with obesity than controls. Conclusion: Non HDL cholesterol is a better predictor of CHD and is comparable to LDL cholesterol in Obese individuals.
Files
IJPCR,Vol15,Issue2,Article113.pdf
Additional details
Dates
- Accepted
-
2023-02-10
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue2,Article113.pdf
- Development Status
- Active
References
- 1. Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease:Olga Castañer, XavierPintó, et al. 2. The Role of Lipids and Lipoproteins in AtherosclerosisMacRae F Linton 1 , Patricia G Yancey 2 et al,In: Endotext [Internet]. South Dartmouth (MA): MD Text.com, Inc.; 2000. 3. Puri R, Nissen SE, Shao M, et al. NonHDL cholesterol and triglycerides: Implications for coronary atheroma progression and clinical events. Arterioscler Thromb Vasc Biol. 2016; 36(11):2220–2228. 4. Faludi AA, Izar MCO, Saraiva JFK, et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose - 2017. Arq Bras Cardiol. 2017; 109(2) Suppl 1:1–76. 5. Fruchart JC, Davignon J, Hermans MP, et al. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014;13(1):26. 6. Wang D, Wang L, Wang Z, Chen S, Ni Y, Jiang D. Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steato hepatitis. Lipids Health Dis. 2018;17(1):67. 7. Barbalho S, Tofano RJ, Bechara MD, Quesada K, Coqueiro DP, Mendes CG. Castelli Index and estimative of LDL-c particle size may still help in the clinical practice? J Cardiovasc Dis Res. 2016; 7(2):86–89. 8. Alibasic E, Ramic E, Bajraktarevic A, Ljuca F, Batic-Mujanovic O, Zildzic M. Atherogenic dyslipidemia and residual vascular risk in practice of family doctor. Med Arh. 2015;69(5):339–341. 9. Costa IFAF, Medeiros CCM, Costa FDAF, et al. Adolescentes: comportamento e risco cardiovascular. J Vasc Bras. 2017; 16(3): 205–213. 10. Puri R, Nissen SE, Shao M, et al. NonHDL cholesterol and triglycerides: Implications for coronary atheroma progression and clinical events. Arterioscler Thromb Vasc Biol. 2016; 36(11):2220–2228. 11. Zeb I, Budoff M. Coronary Artery calcium screening: does it perform better than other cardiovascular risk stratification tools? Int J Mol Sci. 2015;16(3):6606–6620. 12. Faludi AA, Izar MCO, Saraiva JFK, et al. Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose - 2017. Arq Bras Cardiol. 2017;109(2) Suppl 1:1–76. 13. Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: part 1- full report. J Clin Lipidol. 2015;9(2):129–169.