SYNTHESIS AND CHARACTERIZATION OF NEW PYRAZOLINE RING CONTAINED PODOPHYLLOTOXIN ANALOGUES.

Structural and mechanistic aspects of podophyllotoxin have provided the basis for the synthetic endeavours that followed. The most important aryltetralin lignans are found in large quantity in plants of the genus podophyllum. Plants of podophyllum are the main sources of aryl tetralin type lignans. In Berberidaceae plants such as podophyllum emodiwall, podophyllum peltatumlinnaeus, podophyllum pleianthum the cytotoxin lignan lactone and /or antitumour activity producing compound podophyllotoxin is present. The Podophyllum hexandrum rhizomes are known to contain several lignans. Because of Podophyllotoxin definitive biological activity in blocking mitosis and its use as the starting compound of the semi-synthetic chemotherapeutic drugs etoposide, teniposide, and etopophos is used. These antineoplastic pharmaceuticals block DNA toposisomerase II and have been used for the treatment of small and large cell lung, refractory testicular, stomach, pancreatic cancers, and myeloid leukaemia’s .

Key words: Synthesis of 1H-3, 5-diaryl-2-pyrazolines and its derivatives.