Parkinsons-Families-Project

The Parkinson’s Families Project is a UK-wide study aimed at identifying genetic variation associated with familial and early-onset Parkinson's disease (PD). We recruited individuals with a clinical diagnosis of PD and age at motor symptom onset ≤ 45 years and/or a family history of PD in up to third-degree relatives. We analysed DNA samples with a combination of single nucleotide polymorphism (SNP) array genotyping, multiplex ligation-dependent probe amplification (MLPA), and whole-genome sequencing (WGS). We investigated the association between identified pathogenic mutations and demographic and clinical factors such as age at motor symptom onset, family history, motor symptoms (MDS-UPDRS) and cognitive performance (MoCA). Here we present the code used to perform all statistical analyses included in the manuscript.

The following files are necessary to run the code (available to download from https://doi.org/10.5281/zenodo.12549399):

1. PFP_data.csv (clinical and genetic data to run the statistical analyses); a data dictionary is also available that describes each variable.
2. PFP_PRS_model1_normalised.csv (z-transformed PRS, phenotype and covariates to run the PRS analysis)
3. PFP_PRS_model2_normalised.csv (z-transformed PRS, phenotype and covariates to run the PRS analysis)