Formulation And Physiochemical Evaluation Of Polyherbal Toothpaste Using Domestic Medicinal Plants

This study aimed to formulation and evaluation of poly herbal toothpaste using domestic medicinal plants were collected from Butwal Sub-Metropolitan City, Nepal processed and shed dried followed by cold maceration by using distilled water. Herbal Formulation toothpaste (F1) and (F2) were prepared by using herbal extract neem, turmeric, betel, peppermint, guava and other ingredient calcium carbonate, sodium lauryl sulphate, glycerin, gum, saccharin and other preservative. The formulated herbal toothpaste is compared with marketed toothpaste they give beneficial action and safety. The observations were found to be from physical examination appearance, spread ability, pH, homogenecity, foam ability, determination of moisture and volatile matter and anti-bacterial activity. All the samples were screened for antimicrobial activity against Staphylococcus aureus (S. aureus) and Escheria coli (E. coli) bacterial strains by using the disc diffusion method along with standard drug ciprofloxacin. Experimentally it was found that by comparing the formulated and market available herbal toothpaste the value of pH ranges from (7.37 - 7.78), moisture content (11.6 - 17%), Spread ability (4.7 - 5.30 cm) foaming ability lies within (8 - 12 ml). In the antibacterial assay, the (F1) shows 14.93 ± 0.12, (F2) shows 11.9 ± 0.21 mm and market herbal toothpaste shows 19.83 ± 0.20 mm against S. aureus compare with standard ciprofloxacin 25 ± 0.29 mm zone of inhibition (ZOI). However, the extract remained insensitive against E. coli. Therefore, it may be concluded that formulated poly herbal tooth paste also has potential to exhibit anti-microbial activity and has no side effect and they prevent dental caries and dental diseases.