To Determine the Association between Poly Cystic Ovary Syndrome and Thyroid Function Status in a Tertiary Care Hospital in Western Rajasthan
Authors/Creators
- 1. (Ph.D. Medicine Anatomy) Associate Professor, Department of Anatomy, S.P. Medical College, Bikaner, Rajasthan, India
- 2. (MD Pathology) Associate Professor, Department of Pathology, S. P. Medical College, Bikaner, Rajasthan, India
- 3. (MS Anatomy, DMRD) Professor, Department of Anatomy, S.P. Medical College, Bikaner, Rajasthan, India
- 4. (M. Sc Medicine Anatomy) Department of Anatomy, S.P. Medical College, Bikaner, Rajasthan, India
- 5. (M. Sc Medicine Anatomy) Senior Demonstrator, Department of Anatomy, S.P. Medical College, Bikaner, Rajasthan, India
Description
Background: Polycystic ovary syndrome (PCOS), a major and complex endocrine disorder among 5-20% women of reproductive age, is an important health issue which has not yet perceived as a serious concern of public health. Prevalence, aetiology, diagnosis, management, psychological issues, clinical practices and prevention are some most confusing aspects associated with PCOS. PCOS and thyroid dysfunction are commonly found to occur together and both disorders share some common and overlapping features. The exact nature of this link is yet to be elucidated. Both these disorders cause various metabolic, reproductive and psychological syndromes. So, the present study was aimed to determine the association of thyroid function tests in PCOS patients and also to correlate them to body mass index (BMI) and waist -hip ratio (WHR). Methodology: In this cross-sectional study which was performed in Sardar Patel Medical College and Associated group of Hospitals, total 50 subjects were included, out of which 30 were cases (women with polycystic ovary syndrome) and 20 were controls (healthy women). Thyroid function tests which included T3, T4 and TSH were performed for both cases and controls and anthropometric measurements were done for estimating BMI, and waist hip ratio WHR in both the groups. Results: Observations of our study show significant higher levels of TSH (3.83 ± 1.73µIU/ml ; p = 0.0005 ), BMI (25.11±0.57 kg/m2 ; p = 0.0001) and WHR (0.88 ± 0.01 ; p = 0.0001 ) in PCOS patients than controls ( TSH = 2.48 ± 0.72 µIU/ml, BMI = 23.31 ± 1.06 kg/m2, WHR = 0.85 ± 0.02) while level of T3 and T4 was significantly lower T3 (0.88 ± 0.21ng/ml ; p = 0.03), T4 (6.58 ± 1.62 µg/dl ; p = 0.0061) in PCOS patients than Controls(T3 = 1.01 ± 0.18 ng/ml, T4 = 7.63 ± 0.93 µg/dl). Conclusion: Based on our findings, this study demonstrates strong association of hypothyroidism in women with PCOS. It also indicates high fat distribution in PCOS patients. Females with high BMI and WHR should be educated about the complications and made aware to loose wait to improve quality of life. PCR and FISH techniques could be helpful in molecular and cell biology researches. Epigenetic studies would also be helpful for finding the nature of this syndrome. Exposure to sunlight is also essential for women with polycystic ovarian syndrome.
Abstract (English)
Background: Polycystic ovary syndrome (PCOS), a major and complex endocrine disorder among 5-20% women of reproductive age, is an important health issue which has not yet perceived as a serious concern of public health. Prevalence, aetiology, diagnosis, management, psychological issues, clinical practices and prevention are some most confusing aspects associated with PCOS. PCOS and thyroid dysfunction are commonly found to occur together and both disorders share some common and overlapping features. The exact nature of this link is yet to be elucidated. Both these disorders cause various metabolic, reproductive and psychological syndromes. So, the present study was aimed to determine the association of thyroid function tests in PCOS patients and also to correlate them to body mass index (BMI) and waist -hip ratio (WHR). Methodology: In this cross-sectional study which was performed in Sardar Patel Medical College and Associated group of Hospitals, total 50 subjects were included, out of which 30 were cases (women with polycystic ovary syndrome) and 20 were controls (healthy women). Thyroid function tests which included T3, T4 and TSH were performed for both cases and controls and anthropometric measurements were done for estimating BMI, and waist hip ratio WHR in both the groups. Results: Observations of our study show significant higher levels of TSH (3.83 ± 1.73µIU/ml ; p = 0.0005 ), BMI (25.11±0.57 kg/m2 ; p = 0.0001) and WHR (0.88 ± 0.01 ; p = 0.0001 ) in PCOS patients than controls ( TSH = 2.48 ± 0.72 µIU/ml, BMI = 23.31 ± 1.06 kg/m2, WHR = 0.85 ± 0.02) while level of T3 and T4 was significantly lower T3 (0.88 ± 0.21ng/ml ; p = 0.03), T4 (6.58 ± 1.62 µg/dl ; p = 0.0061) in PCOS patients than Controls(T3 = 1.01 ± 0.18 ng/ml, T4 = 7.63 ± 0.93 µg/dl). Conclusion: Based on our findings, this study demonstrates strong association of hypothyroidism in women with PCOS. It also indicates high fat distribution in PCOS patients. Females with high BMI and WHR should be educated about the complications and made aware to loose wait to improve quality of life. PCR and FISH techniques could be helpful in molecular and cell biology researches. Epigenetic studies would also be helpful for finding the nature of this syndrome. Exposure to sunlight is also essential for women with polycystic ovarian syndrome.
Files
IJPCR,Vol15,Issue3,Article98.pdf
Files
(1.9 MB)
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Additional details
Dates
- Accepted
-
2023-03-16
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue3,Article98.pdf
- Development Status
- Active
References
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