Comparative Study on Effect of Rocuronium and Atraconium Induced Rapid Precurarization on Succinylcholine Induced Fasciculations, Post-Operative Myalgias and Intubating Conditions
Authors/Creators
- 1. PG Resident (3rd Year), Department of Anaesthesia, Index Medical College, Hospital & Research Centre, Indore (M.P.)
- 2. Assistant Professor, Department of Anaesthesia, Govt. Bundelkhand Medical College, Sagar, M.P.
- 3. Assistant Professor, Department of Surgery, Govt. Bundelkhand Medical College, Sagar, M.P.
- 4. Senior Resident, Department of Anaesthesia, Govt. G. R. Medical College, Gwalior, M.P.
- 5. Assistant Professor, Department of Community Medicine, Govt. Bundelkhand Medical College, Sagar, M.P.
Description
Background: Succinylcholine gained widespread use rapidly because of its onset is very fast and duration is ultra-short. However, its utility is compromised due to its adverse effects. succinylcholine-induced muscle fasciculations, myalgia is attenuated and prevented by use of multiple drugs. Aims and objectives: To evaluate the rapid precurarization technique using rocuronium and atracurium induced rapid precurarization on succinylcholine induced rapid fasciculations, post-operative myalgias and intubating conditions. Materials and Methods: A comparative observational study comprising of 60 patients was conducted where selected patients either received ROC 0.1 mg/kg or ATR 0.1 mg/kg, and 10 sec later propofol 2 mg / kg IV was given. A balanced anaesthetic technique was used for all patients. Assessment of fasciculations, myalgia and intubating conditions was done using a 4-point rating scale. All patients were evaluated up to the third postoperative day for the presence of POM. Results: The severity and incidence of post-succinylcholine fasciculations decreased in the ROC group as well as in ATR group. However, significant decrease was observed in ROC group. Similarly, a decrease in the severity and incidence of post-succinylcholine myalgia was observed in both the groups, where ROC group showed significant decrease as compared to ATR group. No significant change in the intubating conditions was observed between both the groups. Conclusion: Severity and incidence of post operative myalgia and fasciculation were significantly decreased by pre-treatment with rocuronium in contrast to atraconium. Hence, ROC is a better option than ATR to combat succinylcholine-related complications like fasciculation and myalgia.
Abstract (English)
Background: Succinylcholine gained widespread use rapidly because of its onset is very fast and duration is ultra-short. However, its utility is compromised due to its adverse effects. succinylcholine-induced muscle fasciculations, myalgia is attenuated and prevented by use of multiple drugs. Aims and objectives: To evaluate the rapid precurarization technique using rocuronium and atracurium induced rapid precurarization on succinylcholine induced rapid fasciculations, post-operative myalgias and intubating conditions. Materials and Methods: A comparative observational study comprising of 60 patients was conducted where selected patients either received ROC 0.1 mg/kg or ATR 0.1 mg/kg, and 10 sec later propofol 2 mg / kg IV was given. A balanced anaesthetic technique was used for all patients. Assessment of fasciculations, myalgia and intubating conditions was done using a 4-point rating scale. All patients were evaluated up to the third postoperative day for the presence of POM. Results: The severity and incidence of post-succinylcholine fasciculations decreased in the ROC group as well as in ATR group. However, significant decrease was observed in ROC group. Similarly, a decrease in the severity and incidence of post-succinylcholine myalgia was observed in both the groups, where ROC group showed significant decrease as compared to ATR group. No significant change in the intubating conditions was observed between both the groups. Conclusion: Severity and incidence of post operative myalgia and fasciculation were significantly decreased by pre-treatment with rocuronium in contrast to atraconium. Hence, ROC is a better option than ATR to combat succinylcholine-related complications like fasciculation and myalgia.
Files
IJPCR,Vol15,Issue3,Article3.pdf
Additional details
Dates
- Accepted
-
2023-02-20
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue3,Article3.pdf
- Development Status
- Active
References
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