Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing
Creators
Description
Data collected for the eLife OpenAccess paper: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing. (doi: 10.7554/eLife.92491.1)
Contains: extracted features, calculated stats, normalised z-scores and timerseries data of all the disease model mutants generated. In addition, there is a static .html file that allows for mousing over the clustermaps to easily view differences in strains compared to the N2 wild-type. Dataset also contains, metadata and feature summary/file name information of FDA-library drug screen and the confirmation screen of the hit from this (i.e., all data collected in published in the associated paper).
Files
Systematic creation and phenotyping of Mendelian disease models in C. elegans.zip
Files
(9.2 GB)
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md5:a8744397e885638c715018887badf38a
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Additional details
Funding
- European Research Council
- European Union’s Horizon 2020 research and innovation programme 714853
- Medical Research Council
- Medical Research Council grant MC-A658-5TY30