There is a newer version of the record available.

Published July 8, 2024 | Version v2
Dataset Open

Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

  • 1. ROR icon Imperial College London
  • 2. ROR icon MRC London Institute of Medical Sciences

Description

Data collected for the eLife OpenAccess paper: Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing. (doi: 10.7554/eLife.92491.1)

Contains: extracted features, calculated stats, normalised z-scores and timerseries data of all the disease model mutants generated. In addition, there is a static .html file that allows for mousing over the clustermaps to easily view differences in strains compared to the N2 wild-type. Dataset also contains, metadata and feature summary/file name information of FDA-library drug screen and the confirmation screen of the hit from this (i.e., all data collected in published in the associated paper). 

Files

Systematic creation and phenotyping of Mendelian disease models in C. elegans.zip

Additional details

Funding

European Research Council
European Union’s Horizon 2020 research and innovation programme 714853
Medical Research Council
Medical Research Council grant MC-A658-5TY30