Synthesis, Characterization and Evaluation of Novel 2-Aryl Benzothiazole Derivatives as Potential Antibacterial Agents
Authors/Creators
- 1. Centre for Medicinal Chemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110017
- 2. Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research, New Delhi, 110017
Description
Bacterial resistance to antibacterial agents is of grave concern in the medical community, as many species of bacteria have
evolved as resistant strains. In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The
synthesized benzothiazole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and
1H-NMR) analysis. All the synthesized compounds were screened for their in-vitro antibacterial activity against Grampositive and Gram-negative bacteria. The results revealed that most of the compounds have better activity against
Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard
Gentamicin and Amoxycillin and less active than the standard Ciprofloxacin. Further research can warrant more
consideration on benzothiazoles as prospective antimicrobials.
Abstract (English)
Bacterial resistance to antibacterial agents is of grave concern in the medical community, as many species of bacteria have
evolved as resistant strains. In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The
synthesized benzothiazole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and
1H-NMR) analysis. All the synthesized compounds were screened for their in-vitro antibacterial activity against Grampositive and Gram-negative bacteria. The results revealed that most of the compounds have better activity against
Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard
Gentamicin and Amoxycillin and less active than the standard Ciprofloxacin. Further research can warrant more
consideration on benzothiazoles as prospective antimicrobials.
Files
IJCPR,Vol8,Issue5,Article1 (1).pdf
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Additional details
Dates
- Accepted
-
2017-10-25