To Evaluate the Relationship between the Platelet Count and their Indices MPV, PCT, PDW, PLCC and P-LCR for Diagnosis and Prognosis in Patients with Sepsis. A Prospective Observational Study in Tertiary Care Center
Authors/Creators
- 1. Demonstrator, Department of Pathology, Birsa Munda Government Medical College, Shahdol (M.P.) INDIA
- 2. Designated Professor, NSCB Medical College, Jabalpur (M.P.)
- 3. Assistant Professor, Department of Pathology, Birsa Munda Government Medical College, Shahdol (M.P.) INDIA
- 4. Associate Professor, Department of Pathology, Bundelkhand Medical College, Sagar (M.P.) INDIA
Description
Background: Platelets Count, Mean corpuscular volume (MCV), platelet crit (PCT), platelet distribution width (PDW), PLCC, and platelet-large cell ratio (P-LCR) are commonly used laboratory parameters to assess platelet function in sepsis, a life-threatening condition caused by an overwhelming immune response to infection. Materials and Methods: The platelet count amongst non-survivors and survivors and the MPV, PDW, P-LCR, PLCC and PCT values were among non-survivals and survivals on admission day 1,2 and last day were compared with control group. The platelet indices were obtained from automated haematology analysers, and the results were compared with the reference ranges provided by the manufacturer and to compare platelet indices of cases of sepsis and non-septic patients, platelet indices of control group were also included in our study. Results: A total of 90 patients were included in the study, with a mean age of 44 years (range: 18 to >65 years). The majority of the patients were males (60%) and female is (30%). The platelet count(*109/L) amongst non-survivors and survivors and the MPV (Fl), PDW (%), P-LCR (%), PCT (%), PLCC(*109/L) values were among non-survivals and survivals on day 1,2-4rth and final sample platelets count (231.23±115,254±141.9), (202±114,250.89±185.26), (104±51.9, 197±97.9). MPV (10.75±1.33, 10.54±1.46), (11.20±1.22,10.78±1.20), (11.84±1.17,10.88±1.20), PDW (16.60±0.82, 16.22±0.49), (16.52±0.74, 16.31±0.75), (16.62±0.89,16.30±0.87), P-LCR (41.4±12.47, 40.52±12.17), (47.32±12.79, 43.17±10.06), (53.22±13.77,42.72±9.72), PCT (2.09±1.2, 2.55±1.5), (2.17±1.25,2.66±1.91), (1.50±1.25, 2.46±1.71), PLCC (98±56.9, 83.15±41.7), (89.88±47,101.19±69.62), (71.58±40,101.72±79.62) respectively . Conclusion: Thrombocytopenia is common in sepsis and associated with higher risk of mortality in sepsis. Higher MPV and PDW are associated with poor prognosis. Higher PLCR correlates with increased risk of mortality in sepsis. Lower PCT in sepsis is associated with poor prognosis. Platelet count inversely related to MPV and directly related to plateletcrit. MPV has a strong positive correlation with PLCR as larger platelets contribute to increase in mean platelet volume. MPV has a strong positive correlation with PDW, when MPV increases the PDW tends to be higher. Platelets and its indices are helpful in diagnosis and prognosis of sepsis.
Abstract (English)
Background: Platelets Count, Mean corpuscular volume (MCV), platelet crit (PCT), platelet distribution width (PDW), PLCC, and platelet-large cell ratio (P-LCR) are commonly used laboratory parameters to assess platelet function in sepsis, a life-threatening condition caused by an overwhelming immune response to infection. Materials and Methods: The platelet count amongst non-survivors and survivors and the MPV, PDW, P-LCR, PLCC and PCT values were among non-survivals and survivals on admission day 1,2 and last day were compared with control group. The platelet indices were obtained from automated haematology analysers, and the results were compared with the reference ranges provided by the manufacturer and to compare platelet indices of cases of sepsis and non-septic patients, platelet indices of control group were also included in our study. Results: A total of 90 patients were included in the study, with a mean age of 44 years (range: 18 to >65 years). The majority of the patients were males (60%) and female is (30%). The platelet count(*109/L) amongst non-survivors and survivors and the MPV (Fl), PDW (%), P-LCR (%), PCT (%), PLCC(*109/L) values were among non-survivals and survivals on day 1,2-4rth and final sample platelets count (231.23±115,254±141.9), (202±114,250.89±185.26), (104±51.9, 197±97.9). MPV (10.75±1.33, 10.54±1.46), (11.20±1.22,10.78±1.20), (11.84±1.17,10.88±1.20), PDW (16.60±0.82, 16.22±0.49), (16.52±0.74, 16.31±0.75), (16.62±0.89,16.30±0.87), P-LCR (41.4±12.47, 40.52±12.17), (47.32±12.79, 43.17±10.06), (53.22±13.77,42.72±9.72), PCT (2.09±1.2, 2.55±1.5), (2.17±1.25,2.66±1.91), (1.50±1.25, 2.46±1.71), PLCC (98±56.9, 83.15±41.7), (89.88±47,101.19±69.62), (71.58±40,101.72±79.62) respectively . Conclusion: Thrombocytopenia is common in sepsis and associated with higher risk of mortality in sepsis. Higher MPV and PDW are associated with poor prognosis. Higher PLCR correlates with increased risk of mortality in sepsis. Lower PCT in sepsis is associated with poor prognosis. Platelet count inversely related to MPV and directly related to plateletcrit. MPV has a strong positive correlation with PLCR as larger platelets contribute to increase in mean platelet volume. MPV has a strong positive correlation with PDW, when MPV increases the PDW tends to be higher. Platelets and its indices are helpful in diagnosis and prognosis of sepsis.
Files
IJPCR,Vol15,Issue4,Article68.pdf
Additional details
Dates
- Accepted
-
2023-03-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue4,Article68.pdf
- Development Status
- Active
References
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