Effectiveness of Preoperative Zinc Lozenges for Reduction of Post Operative Sore Throat in Patients Receiving General Anesthesia - A Prospective Randomized Placebo-Controlled Study
Authors/Creators
- 1. Assistant Professor, Department of Anaesthesiology, KPC Medical College & Hospital, Kolkata, West Bengal, India.
Description
Background: Post operative sore throat (POST) is a very common complication among patients undergoing
general anesthesia. Though not very serious but it can significantly reduce patient satisfaction and delay in discharge after day care surgery and reduce turn over. Several methods had been used in the past to reduce it’s incidence. A novel approach is use of zinc lozenges preoperatively utilizing its anti-inflammatory properties to
reduce the incidence of POST.
Methods: This study was designed as randomized placebo-controlled trial with hundred and eight patients, divided into two groups, each containing fifty-four patients. One group received 75 mg zinc lozenges and other
group received placebo. Each patient was assessed for development of POST on a 4-point scale (0-3) at different
time interval. Primary objective was to determine severity of POST at 4 hours after surgery. We also determined
incidence and severity of POST at 0 minutes, 30 minutes, 6 hour and 24 hour after surgery
Result: 3.7% of patients in zinc group developed POST, compared to 48.14% in placebo group (P<0.001) in 4
hour. Overall incidence of POST was 13% in zinc group with a reduction of 52% from placebo group (64.8%).
During initial hours zinc reduced incidence of mild POST, but at 4 hours reduction of severe POST occurred. At
24-hour reduction of POST was not significant.
Conclusion: Preoperative oral administration of 75mg zinc lozenges reduces the incidence of POST during initial postoperative hours (up to 6 hour), with significant reduction of mild POST during first 30 minutes and severe POST in 4 hour time point
Abstract (English)
Background: Post operative sore throat (POST) is a very common complication among patients undergoing
general anesthesia. Though not very serious but it can significantly reduce patient satisfaction and delay in discharge after day care surgery and reduce turn over. Several methods had been used in the past to reduce it’s incidence. A novel approach is use of zinc lozenges preoperatively utilizing its anti-inflammatory properties to
reduce the incidence of POST.
Methods: This study was designed as randomized placebo-controlled trial with hundred and eight patients, divided into two groups, each containing fifty-four patients. One group received 75 mg zinc lozenges and other
group received placebo. Each patient was assessed for development of POST on a 4-point scale (0-3) at different
time interval. Primary objective was to determine severity of POST at 4 hours after surgery. We also determined
incidence and severity of POST at 0 minutes, 30 minutes, 6 hour and 24 hour after surgery
Result: 3.7% of patients in zinc group developed POST, compared to 48.14% in placebo group (P<0.001) in 4
hour. Overall incidence of POST was 13% in zinc group with a reduction of 52% from placebo group (64.8%).
During initial hours zinc reduced incidence of mild POST, but at 4 hours reduction of severe POST occurred. At
24-hour reduction of POST was not significant.
Conclusion: Preoperative oral administration of 75mg zinc lozenges reduces the incidence of POST during initial postoperative hours (up to 6 hour), with significant reduction of mild POST during first 30 minutes and severe POST in 4 hour time point
Files
IJCPR,Vol15,Issue9,Article71.pdf
Additional details
Dates
- Accepted
-
2023-08-28