The Study on the Effect of Cantharidine and Its Derivates on Tumor Cells
Authors/Creators
- 1. Asso. Professor, Arya College of Pharmacy, Jaipur, Rajasthan
- 2. Research Scholar, Arya College of Pharmacy, Jaipur, Rajasthan
Description
Abstract
Millions of people worldwide die from cancer each year, making it the greatest danger to the
survival of the human race. Historically, natural substances have been seen as viable cancer
therapeutic options. Traditional medicine has utilised the terpenoid cantharidin (CTD), which
was extracted from blister beetles, extensively. Chinese drugs to treat cancer and other
diseases. CTD has been shown to inhibit both the heat shock transcription factor 1 (HSF-1)
and protein phosphatase 2A (PP2A), which are possible targets for its anticancer effect. Even
though it contains certain toxins, CTD's tremendous anticancer potential cannot be
understated since cancer-specific delivery of the drug might mitigate its fatal consequences.
Additionally, a number of compounds have been created to lessen its toxicity. The anticancer
action of CTD is shown in both in light of substantial studies, both in vitro and in vivo cancer
models exist. Additionally effective when used in conjunction with radiation and
chemotherapy, CTD can also target some cancer cells that have developed a resistance to
certain drugs. The goal of this mini-review is to analyse and condense current findings about
the molecular underpinnings and anticancer potential of CTD. CTD's relevant anticancer
properties might be used to create a potent anticarcinogenic medication
Abstract (English)
Abstract
Millions of people worldwide die from cancer each year, making it the greatest danger to the
survival of the human race. Historically, natural substances have been seen as viable cancer
therapeutic options. Traditional medicine has utilised the terpenoid cantharidin (CTD), which
was extracted from blister beetles, extensively. Chinese drugs to treat cancer and other
diseases. CTD has been shown to inhibit both the heat shock transcription factor 1 (HSF-1)
and protein phosphatase 2A (PP2A), which are possible targets for its anticancer effect. Even
though it contains certain toxins, CTD's tremendous anticancer potential cannot be
understated since cancer-specific delivery of the drug might mitigate its fatal consequences.
Additionally, a number of compounds have been created to lessen its toxicity. The anticancer
action of CTD is shown in both in light of substantial studies, both in vitro and in vivo cancer
models exist. Additionally effective when used in conjunction with radiation and
chemotherapy, CTD can also target some cancer cells that have developed a resistance to
certain drugs. The goal of this mini-review is to analyse and condense current findings about
the molecular underpinnings and anticancer potential of CTD. CTD's relevant anticancer
properties might be used to create a potent anticarcinogenic medication
Files
IJCPR,Vol15,Issue6,Article25.pdf
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Additional details
Dates
- Accepted
-
2023-06-10