Prevalence of Impaired Fasting Glucose and Impaired Glucose Tolerance in the First-Degree Relatives of Patients with Type 2 Diabetes Mellitus

Description

Abstract (English)

Abstract
Background and Objectives: Prediabetes is characterized by impaired fasting glucose (IFG)
and impaired glucose tolerance (IGT). It poses a higher risk of progressing to diabetes,
particularly in first-degree relatives (FDRs) of individuals with Type 2 diabetes. This study
aimed to assess the prevalence of IFG and IGT in FDRs of individuals diagnosed with Type 2
diabetes mellitus (T2DM).
Materials & Methods: 300 participants (201 males and 99 females) who were FDRs of
patients with T2DM, aged 18 years and above, were selected from rural area of central
Madhya Pradesh. Fasting blood sugar (FBS) and 2-hour postglucose blood sugar (PG2BS)
levels were measured using a fully automated analyzer employing the enzymatic
colorimetric.
Results: The study revealed that prevalence of IFG among FDRs of individuals with T2DM
was approximately 15.1%. Additionally, 12% of the participants were newly diagnosed with
diabetes based on their FBS levels. Notably, only 14% of the subjects exhibited impaired
PG2BS levels, and the prevalence of diabetes determined by this method closely aligned with
the FBS method.
Conclusion: The prevalence of diabetes is rapidly increasing, even in rural India. There is
urgent need for preventive measures and interventions to curb the escalating rates and
promote better health outcomes in these communities.