Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Bihar, North India: An Evaluation of Clinic Mycological Association and Antifungal Susceptibility Pattern
Authors/Creators
- 1. Tutor, Department of Microbiology, Nalanda Medical College Hospital Patna, Bihar, India
- 2. Tutor, Department of Microbiology, Nalanda Medical College Hospital, Patna, Bihar
Description
Objective: The purpose of this study was to examine the prevalence and associated risk factors for oral candidiasis among cancer patients seeking treatment at a tertiary care hospital Bihar, and to determine the antifungal susceptibility pattern among these patients. Methodology: A cross-sectional study was conducted on 100 cancer patients who presented with clinical features of oral candidiasis at a tertiary care hospital in Bihar from January 2023 to April 2023. Clinical and mycological evaluations were performed to identify Candida species and determine antifungal susceptibility patterns. Statistical analysis was performed to evaluate the clinicomycological association and antifungal susceptibility pattern. Results: The prevalence of oral candidiasis among cancer patients in this study was found to be 52%. Candida albicans was the most commonly isolated species, followed by Candida tropicalis. Antifungal susceptibility testing revealed that most isolates were susceptible to fluconazole, while resistance to amphotericin B was observed in a small percentage of isolates. Significant clinic mycological associations were found between the severity of oral candidiasis and the use of broad-spectrum antibiotics. Conclusion: This study highlights the importance of appropriate use of broad-spectrum antibiotics to prevent the development of oral candidiasis among cancer patients. The findings of this study can inform the development of effective treatment guidelines for the management of oral candidiasis among cancer patients in Bihar. The study’s contributions to the existing literature on oral candidiasis among cancer patients underscore the significance of understanding the prevalence, etiology, and management of this condition in developing countries such as India.
Abstract (English)
Objective: The purpose of this study was to examine the prevalence and associated risk factors for oral candidiasis among cancer patients seeking treatment at a tertiary care hospital Bihar, and to determine the antifungal susceptibility pattern among these patients. Methodology: A cross-sectional study was conducted on 100 cancer patients who presented with clinical features of oral candidiasis at a tertiary care hospital in Bihar from January 2023 to April 2023. Clinical and mycological evaluations were performed to identify Candida species and determine antifungal susceptibility patterns. Statistical analysis was performed to evaluate the clinicomycological association and antifungal susceptibility pattern. Results: The prevalence of oral candidiasis among cancer patients in this study was found to be 52%. Candida albicans was the most commonly isolated species, followed by Candida tropicalis. Antifungal susceptibility testing revealed that most isolates were susceptible to fluconazole, while resistance to amphotericin B was observed in a small percentage of isolates. Significant clinic mycological associations were found between the severity of oral candidiasis and the use of broad-spectrum antibiotics. Conclusion: This study highlights the importance of appropriate use of broad-spectrum antibiotics to prevent the development of oral candidiasis among cancer patients. The findings of this study can inform the development of effective treatment guidelines for the management of oral candidiasis among cancer patients in Bihar. The study’s contributions to the existing literature on oral candidiasis among cancer patients underscore the significance of understanding the prevalence, etiology, and management of this condition in developing countries such as India.
Files
IJPCR,Vol15,Issue5,Article72.pdf
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Additional details
Dates
- Accepted
-
2023-05-08
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue5,Article72.pdf
- Development Status
- Active
References
- 1. H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray, Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA: A Cancer Journal for Clinicians, 2021; 71(3): 209–249. 2. X. Chen, K. Li, Z. Liu, F. Gai, G. Zhu, S. Lu, and N. Che, Multigene PCR using both cfdna and cfrna in the supernatant of pleural effusion achieves accurate and rapid detection of mutations and fusions of driver genes in patients with advanced NSCLC, Cancer Medicine, 2021;10(7): 2286–2292. 3. T. G. Qiu, Trabodenoson on Trabecular Meshwork rejuvenation: A comprehensive review of clinical data, Expert Opinion on Investigational Drugs, 2021; 30(3): 227–236, 2021. 4. E. Lotfali, M. Mardani, S. Abolghasemi, D. Darvishnia, M. M. Rabiei, R. Ghasemi, and A. Fattahi, "Isolation of candida africana in oral candidiasis: First report among cancer patients in Iran," Current Medical Mycology, 2020. 5. V. Hodiwala, H. B. Kar, and A. Singh, Study of oral candidiasis in HIV / AIDS patients and their antifungal susceptibility pattern, Journal of Evolution of Medical and Dental Sciences, 2021; 10(6): 338–341, 2021. 6. I.A. Tamai, B. Pakbin, and B. N. Fasaei, Genetic diversity and antifungal susceptibility of candida albicans strains isolated from Lranian HIV+ patients with oral candidiasis, 2020. 7. G. A. Pesewu, P. K. Feglo, R. K. Boateng, and S. A. Fayemiwo, Prevalence and antifungal susceptibility pattern of candida isolates from women with recurrent vulvovaginal candidiasis in Ghana - a review of laboratory reports., 2020. 8. S. Gupta and H. B. Gadekar, Antifungal susceptibility pattern of candida albicans and non-candida albicans species isolates at a tertiary care hospital in India, Journal of Pharmaceutical Research International, 2021; 72–80. 9. N. Goel, S. W. Fatima, S. Kumar, R. Sinha, and S. K. Khare, Antimicrobial resistance in biofilms: Exploring marine actinobacteria as a potential source of antibiotics and biofilm inhibitors, Biotechnology Reports, 2021;30. 10. Y.L. Dong, W.F. Hou, C. Zhang, X.Z. Cao, and Z.Y. Li, Effectiveness of honey on radiation-induced oral mucositis among patients with head and neck malignancies: A systematic review and meta-analysis, Current Topics in Nutraceutical Research, 2022; 21(1): 53– 59. 11. M. K. Sharma, Metagenomic analysis of oral microbiota among oral cancer patients and tobacco chewers in Rajasthan, India, Bioinformation, 2022; 18(9): 757–763. 12. Amit Kumar Singh, Dakshina Bisht, Jitendra Kumar Chaudhary, and Desh Nidhi Singh, antifungal susceptibility pattern of oropharyngeal candidiasis in cancer patients, Journal ofPharmaceutical Negative Results, 2022; 458–463. 13. S. Krishnan, Evaluation of patterns in mandibular fractures among North Indian patients, Bioinformation, 2022; 18(6): 566–571.