A Case Control Study Evaluating Thyroid Profile in Patients of Liver Cirrhosis: An Observational Study
Authors/Creators
- 1. Senior Resident, Department of General Medicine, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India
- 2. Associate Professor, Department of General Medicine, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India
Description
Abstract
Aim: This study was conducted to study thyroid dysfunction in patients of liver cirrhosis and any association
between severity of liver cirrhosis and thyroid profile.
Methods: This case-control study was conducted in the Department of Medicine. A total of 200 liver cirrhosis
patients (case) and equal number (200) of healthy controls were included in this study. The study was conducted
for the period of two years.
Results: A total of 200 liver cirrhosis cases (150 males and 50 females) and 200 apparently healthy controls
(120 males and 80 females) were included in the final analysis. The mean age was 46.34 ± 8.24 years for cases
and 47.23 ± 6.34 years for controls. Controls as compared to cases had higher free T3 (fT3) (2.48 ± 0.44 vs.
1.64 ± 0.52 pg/ml) and free T4 (fT4) (1.28 ± 0.32 vs. 1.16 ± 0.46 ng/ml), although the difference was significant
only for free T3. On the contrary, TSH values of cases were found to be significantly higher as compared to that
of controls (3.57 ± 0.90 vs. 3.02 ± 0.64 μIU/ml). Low T3 syndrome and hypothyroidism were common thyroid
disorders (24% and 18%), normal thyroidal illness syndrome with low T4 and high T4 were observed among
16% and 12% cases, whereas out of 200 controls, 180 (90%) did not have any abnormality in thyroid functions.
Only 14 (7%) cases were diagnosed as normal thyroidal illness syndrome with high T4 abnormality. The
difference in thyroid dysfunctions between cases and controls was found to be significant statistically.
Conclusion: Liver disease cases as compared to controls had significantly lower fT3 levels and significantly
higher TSH levels. Mortality rate of liver disease cases with thyroid dysfunction was also found to be
significantly higher
Abstract (English)
Abstract
Aim: This study was conducted to study thyroid dysfunction in patients of liver cirrhosis and any association
between severity of liver cirrhosis and thyroid profile.
Methods: This case-control study was conducted in the Department of Medicine. A total of 200 liver cirrhosis
patients (case) and equal number (200) of healthy controls were included in this study. The study was conducted
for the period of two years.
Results: A total of 200 liver cirrhosis cases (150 males and 50 females) and 200 apparently healthy controls
(120 males and 80 females) were included in the final analysis. The mean age was 46.34 ± 8.24 years for cases
and 47.23 ± 6.34 years for controls. Controls as compared to cases had higher free T3 (fT3) (2.48 ± 0.44 vs.
1.64 ± 0.52 pg/ml) and free T4 (fT4) (1.28 ± 0.32 vs. 1.16 ± 0.46 ng/ml), although the difference was significant
only for free T3. On the contrary, TSH values of cases were found to be significantly higher as compared to that
of controls (3.57 ± 0.90 vs. 3.02 ± 0.64 μIU/ml). Low T3 syndrome and hypothyroidism were common thyroid
disorders (24% and 18%), normal thyroidal illness syndrome with low T4 and high T4 were observed among
16% and 12% cases, whereas out of 200 controls, 180 (90%) did not have any abnormality in thyroid functions.
Only 14 (7%) cases were diagnosed as normal thyroidal illness syndrome with high T4 abnormality. The
difference in thyroid dysfunctions between cases and controls was found to be significant statistically.
Conclusion: Liver disease cases as compared to controls had significantly lower fT3 levels and significantly
higher TSH levels. Mortality rate of liver disease cases with thyroid dysfunction was also found to be
significantly higher
Files
IJCPR,Vol15,Issue8,Article61.pdf
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Additional details
Dates
- Accepted
-
2023-03-25