A Clinical Study on the Correlation between Primary Open Angle Glaucoma and Serum Lipids
Authors/Creators
- 1. Associate Professor, Department of Ophthalmology, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Bangalore, Karnataka, India
- 2. Professor, Department of Ophthalmology, Akash Institute of Medical Sciences and Research Centre,Devanahalli, Bangalore, Karnataka, India
Description
Background: One of the leading causes of blindness in the world is Glaucoma. The primary risk factor is Intra Ocular Pressure. But some cases progress even with control of intra ocular pressure. This substantiates the view that there are independent risk factors in pathogenesis of Glaucoma. This study was carried out by us to study the relation between Primary Open Angle Glaucoma and Serum Lipids. Methods and Materials: This study was conducted on 45 patients with POAG and 45 individuals without Glaucoma (Controls). Ophthalmic examination was performed on all patients and Fasting Lipid profile including Total Cholesterol, Low density lipoprotein, High Density Lipoprotein and Triglycerides were measured and analysed between cases and controls. Results: It was noted that the level of total cholesterol, total glycerol and LDL were significantly higher in cases than in controls with P values < 0.06. level of HDL was lower in controls but it was not statistically significant. Conclusion: Dyslipidemia is an independent risk factor for POAG. High levels of Serum Cholesterol, Serum Triglycerides and serum LDL corelate significantly with POAG.
Abstract (English)
Background: One of the leading causes of blindness in the world is Glaucoma. The primary risk factor is Intra Ocular Pressure. But some cases progress even with control of intra ocular pressure. This substantiates the view that there are independent risk factors in pathogenesis of Glaucoma. This study was carried out by us to study the relation between Primary Open Angle Glaucoma and Serum Lipids. Methods and Materials: This study was conducted on 45 patients with POAG and 45 individuals without Glaucoma (Controls). Ophthalmic examination was performed on all patients and Fasting Lipid profile including Total Cholesterol, Low density lipoprotein, High Density Lipoprotein and Triglycerides were measured and analysed between cases and controls. Results: It was noted that the level of total cholesterol, total glycerol and LDL were significantly higher in cases than in controls with P values < 0.06. level of HDL was lower in controls but it was not statistically significant. Conclusion: Dyslipidemia is an independent risk factor for POAG. High levels of Serum Cholesterol, Serum Triglycerides and serum LDL corelate significantly with POAG.
Files
IJPCR,Vol15,Issue6,Article148.pdf
Files
(304.6 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:2f60627ab97bbe26a1db60db62586465
|
304.6 kB | Preview Download |
Additional details
Dates
- Accepted
-
2023-05-06
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue6,Article148.pdf
- Development Status
- Active
References
- 1. Pavljasevic S, Asceric M. Primary open- angle glaucoma and serum lipids. Boon j Basic Med Sci 2009 ; 9: 85-8. 2. George R, Ve RS, Vijaya L. Glaucoma in India: estimated burden of disease. J Glaucoma 2010; 19: 391-7 3. Egorow W, Bachaldin IL, Sorokin EF. Characteristics of morphological and functional state of erythrocytes in patients with POAG with normalized intra ocular pressure, vestn ophthalmol 2001; 117 5-8 4. Executive summary of third report of National cholesterol education program (NCEP), expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Jama 2001 ;285:2486-2497. 5. McGwin G Jr, McNeal S, Owsley C, Girkin C, Epstein D, Lee PP. Statins and other cholesterol lowering medications and the presence of glaucoma. Arch Ophthalmol 2004;122:822-826 6. Kumar DM, Agarwal N. Oxidative stress in glaucoma: a burden of evidence. j Glaucoma 2007; 16: 334-43 7. Chisholm IA, Stead S. Plasma lipid patterns in patients with suspected glaucoma. Cn J Ophthalmol 1988; 23:164-7 8. Newmann -Casey PA, Talwar N, Nan B, Musch DC, SteinJD. The relationship between components of metabolic syndrome and open angle glaucoma . Ophthalmology 2011; 118:1318-26 9. Sihota, Ramanjit and Tandon, Radhika. The Glaucomas In: Parson's diseases of the eye. 21st ed.Elsevier 2013: 280.10. Nichenig G, HarrisonG. The AT(1)- TYPE Angiotensin receptor in oxidative stress and atherogenesis: part 1: Oxidative stress and atherogenesis. Circulation 2002 ;105:393-6.