suny-downstate-medical-center/pd_m1_6ohda: M1_Control_6OHDA

<h1>Pyramidal tract neurons and Parkinson's disease in simulated mouse primary motor cortex</h1> <p>Pyramidal tract neurons are the most direct output to muscles from the primary motor cortex (M1). <a href="https://www.jneurosci.org/content/41/25/5553">Liqiang Chu et al (2021)</a> have shown that layer 5 pyramidal tract neurons (PT5B) decrease in excitability in parkinsonian as compared with control M1 in mice treated with 6-OHDA. We built this simulation, based on a <a href="https://github.com/suny-downstate-medical-center/netpyne/tree/development/examples/M1detailed">detailed motor cortex implementation in NetPyNE</a>, to see how the changed PT5B neuron excitability changes M1 spiking dynamics.</p> <p><a href="http://doc.netpyne.org/">NetPyNE</a> is a Python package for creating biological neural networks using the <a href="https://nrn.readthedocs.io">NEURON</a> simulator.</p> <p>Get the preprint <a href="https://www.biorxiv.org/content/10.1101/2024.05.23.595566v1">Donald W. Doherty et al. (2024).</a></p> <h2>Acknowlegements</h2> <p>This research was funded by Aligning Science Across Parkinson's [ASAP-020572] through the Michael J. Fox Foundation for Parkinson's Research (MJFF).</p>