Published August 22, 1985
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Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
Description
The partial amino-acid sequence of purified human transforming growth factor-β (TGF-β) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-β messenger RNA is synthesized in various normal and transformed cells.
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